ICI 174,864

Pricing Availability   Qty
Description: δ selective peptide antagonist
Purity: ≥95% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (2)

Biological Activity for ICI 174,864

ICI 174,864 is a selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for ICI 174,864

M. Wt 691.87
Formula C38H53N5O7
Sequence YXXFL

(Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 89352-67-0
PubChem ID 44149909
InChI Key XUWLAGNFLUARAN-CHQNGUEUSA-N
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ICI 174,864

Solubility Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water

Product Datasheets for ICI 174,864

Certificate of Analysis / Product Datasheet
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References for ICI 174,864

References are publications that support the biological activity of the product.

Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID: 2875170

Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331 PMID: 6323195

Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311 PMID: 2987731

Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383 PMID: 2987739


If you know of a relevant reference for ICI 174,864, please let us know.

View Related Products by Product Action

View all δ Opioid Receptor Antagonists

Keywords: ICI 174,864, ICI 174,864 supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Delta, Opioid, 0820, Tocris Bioscience

5 Citations for ICI 174,864

Citations are publications that use Tocris products. Selected citations for ICI 174,864 include:

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511

Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753

Gallego et al (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol 18 737 PMID: 18803462

Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556 PMID: 10516632


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.