Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
Sold with the permission of AstraZeneca UK Ltd.
(Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 691.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.45 mL||7.23 mL||14.45 mL|
|5 mM||0.29 mL||1.45 mL||2.89 mL|
|10 mM||0.14 mL||0.72 mL||1.45 mL|
|50 mM||0.03 mL||0.14 mL||0.29 mL|
References are publications that support the products' biological activity.
Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID: 2875170
Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331 PMID: 6323195
Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311 PMID: 2987731
Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383 PMID: 2987739
If you know of a relevant reference for ICI 174,864, please let us know.
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Keywords: ICI 174,864, supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Delta, Opioid, Receptors, Delta, Opioid, Receptors, Tocris Bioscience
3 Citations for ICI 174,864
Citations are publications that use Tocris products. Selected citations for ICI 174,864 include:
Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556 PMID: 10516632
Gallego et al (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol 18 737 PMID: 18803462
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511
Do you know of a great paper that uses ICI 174,864 from Tocris? If so please let us know.
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