ICI 174,864

Pricing Availability   Qty
Cat.No. 0820 - ICI 174,864 | N,N-diallyl-Tyr-Aib-Aib-Phe-Leu | CAS No. 89352-67-0
Description: δ selective peptide antagonist
Datasheet
Citations (5)
Reviews
Literature (5)

Biological Activity

Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 691.87
Formula C38H53N5O7
Sequence YXXFL

(Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)

Storage Desiccate at -20°C
CAS Number 89352-67-0
PubChem ID 44149909
InChI Key XUWLAGNFLUARAN-CHQNGUEUSA-N
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID: 2875170

Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331 PMID: 6323195

Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311 PMID: 2987731

Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383 PMID: 2987739


If you know of a relevant reference for ICI 174,864, please let us know.

View Related Products by Product Action

View all δ Opioid Receptor Antagonists

Keywords: ICI 174,864, ICI 174,864 supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Delta, Opioid, 0820, Tocris Bioscience

5 Citations for ICI 174,864

Citations are publications that use Tocris products. Selected citations for ICI 174,864 include:

Gallego et al (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol 18 737 PMID: 18803462

Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556 PMID: 10516632

Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753

Leroy et al (2017) Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron 95 1089 PMID: 28823730


Do you know of a great paper that uses ICI 174,864 from Tocris? Please let us know.

Reviews for ICI 174,864

There are currently no reviews for this product. Be the first to review ICI 174,864 and earn rewards!

Have you used ICI 174,864?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.