ICI 174,864

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Cat.No. 0820 - ICI 174,864 | N,N-diallyl-Tyr-Aib-Aib-Phe-Leu | CAS No. 89352-67-0
Description: δ selective peptide antagonist
Citations (5)
Literature (5)

Biological Activity

Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 691.87
Formula C38H53N5O7
Sequence YXXFL

(Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)

Storage Desiccate at -20°C
CAS Number 89352-67-0
PubChem ID 44149909
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID: 2875170

Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331 PMID: 6323195

Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311 PMID: 2987731

Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383 PMID: 2987739

If you know of a relevant reference for ICI 174,864, please let us know.

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Keywords: ICI 174,864, ICI 174,864 supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Delta, Opioid, 0820, Tocris Bioscience

5 Citations for ICI 174,864

Citations are publications that use Tocris products. Selected citations for ICI 174,864 include:

Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753

Gallego et al (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol 18 737 PMID: 18803462

Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556 PMID: 10516632

Leroy et al (2017) Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron 95 1089 PMID: 28823730

Do you know of a great paper that uses ICI 174,864 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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