ICI 174,864

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Cat.No. 0820 - ICI 174,864 | N,N-diallyl-Tyr-Aib-Aib-Phe-Leu | CAS No. 89352-67-0
Description: δ selective peptide antagonist
Datasheet
Citations (3)
Literature

Biological Activity

Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 691.87
Formula C38H53N5O7
Sequence YXXFL

(Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)

Storage Desiccate at -20°C
CAS Number 89352-67-0
PubChem ID 44149909
InChI Key XUWLAGNFLUARAN-CHQNGUEUSA-N
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 691.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.45 mL 7.23 mL 14.45 mL
5 mM 0.29 mL 1.45 mL 2.89 mL
10 mM 0.14 mL 0.72 mL 1.45 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID: 2875170

Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331 PMID: 6323195

Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311 PMID: 2987731

Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383 PMID: 2987739


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Keywords: ICI 174,864, supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Delta, Opioid, Receptors, Tocris Bioscience

3 Citations for ICI 174,864

Citations are publications that use Tocris products. Selected citations for ICI 174,864 include:

Gallego et al (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol 18 737 PMID: 18803462

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511

Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556 PMID: 10516632


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