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Selective peptide agonist for the δ opioid receptor. Antinociceptive in vivo.
(Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Mattia et al (1991) Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes. J.Pharmacol.Exp.Ther. 258 583 PMID: 1650835
Sanchez-Blazquez (1998) Delta opioid receptor subtypes activate inositol-signalling pathways in the production of antinociception. J.Pharmacol.Exp.Ther. 285 820 PMID: 9580632
Thomas et al (1997) Structure-activity relationships of a series of [D-Ala2] deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J.Pharmacol.Exp.Ther. 281 817 PMID: 9152390
If you know of a relevant reference for [D-Ala2]-Deltorphin II, please let us know.
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Keywords: [D-Ala2]-Deltorphin II, [D-Ala2]-Deltorphin II supplier, Selective, δ-opioid, delta-opioid, agonist, peptide, DOP, Receptors, OP1, [D-Ala2]-DeltorphinII, Delta, Opioid, 1180, Tocris Bioscience
4 Citations for [D-Ala2]-Deltorphin II
Citations are publications that use Tocris products. Selected citations for [D-Ala2]-Deltorphin II include:
Kharmate et al (2013) Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int 13 93 PMID: 24059654
Krook-Magnuson et al (2011) Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation. J Neurosci 31 14861 PMID: 22016519
Laurent et al (2014) δ-opioid and DArgic processes in accumbens shell modulate the cholinergic control of predictive learning and choice. J Neurosci 34 1358 PMID: 24453326
Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Arthritis Res Ther 172 642 PMID: 24827408
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