[D-Ala2]-Deltorphin II

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Cat.No. 1180 - [D-Ala2]-Deltorphin II | Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 | CAS No. 122752-16-3
Description: Selective δ agonist peptide
Datasheet
Citations (4)
Reviews
Literature (5)

Biological Activity

Selective peptide agonist for the δ opioid receptor. Antinociceptive in vivo.

Technical Data

M. Wt 782.89
Formula C38H54N8O10
Sequence YAFEVVG

(Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 122752-16-3
PubChem ID 10033203
InChI Key NUNBRHVOPFWRRG-RCEFDBTISA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mattia et al (1991) Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes. J.Pharmacol.Exp.Ther. 258 583 PMID: 1650835

Sanchez-Blazquez (1998) Delta opioid receptor subtypes activate inositol-signalling pathways in the production of antinociception. J.Pharmacol.Exp.Ther. 285 820 PMID: 9580632

Thomas et al (1997) Structure-activity relationships of a series of [D-Ala2] deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J.Pharmacol.Exp.Ther. 281 817 PMID: 9152390


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Keywords: [D-Ala2]-Deltorphin II, [D-Ala2]-Deltorphin II supplier, Selective, δ-opioid, delta-opioid, agonist, peptide, DOP, Receptors, OP1, [D-Ala2]-DeltorphinII, Delta, Opioid, 1180, Tocris Bioscience

4 Citations for [D-Ala2]-Deltorphin II

Citations are publications that use Tocris products. Selected citations for [D-Ala2]-Deltorphin II include:

Kharmate et al (2013) Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int 13 93 PMID: 24059654

Krook-Magnuson et al (2011) Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation. J Neurosci 31 14861 PMID: 22016519

Laurent et al (2014) δ-opioid and DArgic processes in accumbens shell modulate the cholinergic control of predictive learning and choice. J Neurosci 34 1358 PMID: 24453326

Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Arthritis Res Ther 172 642 PMID: 24827408


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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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