[D-Ala2]-Deltorphin II

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Cat.No. 1180 - [D-Ala2]-Deltorphin II | Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 | CAS No. 122752-16-3
Description: Selective δ agonist peptide
Datasheet
Citations (3)
Literature

Biological Activity

Selective peptide agonist for the δ opioid receptor. Antinociceptive in vivo.

Technical Data

M. Wt 782.89
Formula C38H54N8O10
Sequence YAFEVVG

(Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 122752-16-3
PubChem ID 10033203
InChI Key NUNBRHVOPFWRRG-RCEFDBTISA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 782.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.39 mL 12.77 mL
5 mM 0.26 mL 1.28 mL 2.55 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Mattia et al (1991) Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes. J.Pharmacol.Exp.Ther. 258 583 PMID: 1650835

Sanchez-Blazquez (1998) Delta opioid receptor subtypes activate inositol-signalling pathways in the production of antinociception. J.Pharmacol.Exp.Ther. 285 820 PMID: 9580632

Thomas et al (1997) Structure-activity relationships of a series of [D-Ala2] deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J.Pharmacol.Exp.Ther. 281 817 PMID: 9152390


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View all δ Opioid Receptor Agonists

Keywords: [D-Ala2]-Deltorphin II, supplier, Selective, δ-opioid, delta-opioid, agonist, peptide, DOP, Receptors, OP1, [D-Ala2]-DeltorphinII, Delta, Opioid, Receptors, Delta, Opioid, Receptors, Tocris Bioscience

3 Citations for [D-Ala2]-Deltorphin II

Citations are publications that use Tocris products. Selected citations for [D-Ala2]-Deltorphin II include:

Kharmate et al (2013) Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int 13 93 PMID: 24059654

Krook-Magnuson et al (2011) Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation. J Neurosci 31 14861 PMID: 22016519

Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Arthritis Res Ther 172 642 PMID: 24827408


Do you know of a great paper that uses [D-Ala2]-Deltorphin II from Tocris? If so please let us know.

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