BMS 986187

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Description: Potent positive allosteric modulator of δ receptors
Chemical Name: 3,4,5,6,7,9-Hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for BMS 986187

BMS 986187 is a potent δ-opioid receptor positive allosteric modulator (EC50 = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.

Compound Libraries for BMS 986187

BMS 986187 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 986187

M. Wt 470.61
Formula C31H34O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 684238-37-7
PubChem ID 17379334
Smiles CC(C=CC=C1)=C1COC2=CC=C(C=C2)C3C4=C(CC(C)(C)CC4=O)OC5=C3C(CC(C)(C)C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 986187

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.41 20

Preparing Stock Solutions for BMS 986187

The following data is based on the product molecular weight 470.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.62 mL 53.12 mL 106.25 mL
1 mM 2.12 mL 10.62 mL 21.25 mL
2 mM 1.06 mL 5.31 mL 10.62 mL
10 mM 0.21 mL 1.06 mL 2.12 mL

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References for BMS 986187

References are publications that support the biological activity of the product.

Burford et al (2015) Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 58 4220 PMID: 25901762

Shang et al (2016) Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 11 1220 PMID: 26841170

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Citations for BMS 986187

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Literature in this Area

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