BMS 986187

Pricing Availability Delivery Time Qty
Cat.No. 5983 - BMS 986187 | C31H34O4 | CAS No. 684238-37-7
Description: Potent δ-opioid receptor positive allosteric modulator
Chemical Name: 3,4,5,6,7,9-Hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent δ-opioid receptor positive allosteric modulator (EC50 = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.

Technical Data

M. Wt 470.61
Formula C31H34O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 684238-37-7
PubChem ID 17379334
InChI Key UEKIYVKPQNKSDI-UHFFFAOYSA-N
Smiles CC(C=CC=C1)=C1COC2=CC=C(C=C2)C3C4=C(CC(C)(C)CC4=O)OC5=C3C(CC(C)(C)C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.41 20

Preparing Stock Solutions

The following data is based on the product molecular weight 470.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.62 mL 21.25 mL
5 mM 0.42 mL 2.12 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References

References are publications that support the products' biological activity.

Burford et al (2015) Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 58 4220 PMID: 25901762

Shang et al (2016) Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 11 1220 PMID: 26841170


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Keywords: BMS986187 potent delta-opioid receptors d-opioid δ-opioid positive allosteric modulators PAMs Delta Opioid Receptors

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