Pricing Availability   Qty
Description: Selective δ agonist
Alternative Names: [D-Pen2,5]Enkephalin,[D-Pen2,D-Pen5]Enkephalin
Purity: ≥95% (HPLC)
Citations (12)
Literature (2)

Biological Activity for DPDPE

DPDPE is a prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.

Technical Data for DPDPE

M. Wt 645.79
Formula C30H39N5O7S2
Sequence YXGFX

(Modifications: X = D-Pen, Disulfide bridge: 2-5)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 88373-73-3
PubChem ID 14679813
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](C(O)=O)C(C)(C)SSC1(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DPDPE

Solubility Soluble to 1 mg/ml in water

Product Datasheets for DPDPE

Certificate of Analysis / Product Datasheet
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References for DPDPE

References are publications that support the biological activity of the product.

Chandrakumar et al (1992) Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. J.Med.Chem. 35 2928 PMID: 1323677

Clark et al (1986) [D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites. Eur.J.Pharmacol. 128 303 PMID: 3025000

Fraser et al (2000) Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat. J.Pharmacol.Exp.Ther. 295 1135 PMID: 11082450

If you know of a relevant reference for DPDPE, please let us know.

View Related Products by Product Action

View all δ Opioid Receptor Agonists

Keywords: DPDPE, DPDPE supplier, Selective, agonists, δ-opioid, delta-opioid, d-opioid, DOP, Receptors, OP1, delta-receptor, [D-Pen2,5]Enkephalin, [D-Pen2,D-Pen5]Enkephalin, Delta, Opioid, 1431, Tocris Bioscience

12 Citations for DPDPE

Citations are publications that use Tocris products. Selected citations for DPDPE include:

Niu et al (2011) Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition. Neuroscience 180 344 PMID: 21296645

Morse et al (2011) Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS One 6 e25643 PMID: 22003401

Tsitoura et al (2015) Inhibition of Anopheles gambiae odorant receptor function by mosquito repellents. J Biol Chem 290 7961 PMID: 25657000

Dunning et al (2016) Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein. J Neurochem 137 518 PMID: 26865271

Do you know of a great paper that uses DPDPE from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.