Prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
(Modifications: X = D-Pen, Disulfide bridge between 2 - 5)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 645.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.55 mL||7.74 mL||15.48 mL|
|5 mM||0.31 mL||1.55 mL||3.1 mL|
|10 mM||0.15 mL||0.77 mL||1.55 mL|
|50 mM||0.03 mL||0.15 mL||0.31 mL|
References are publications that support the products' biological activity.
Chandrakumar et al (1992) Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. J.Med.Chem. 35 2928 PMID: 1323677
Clark et al (1986) [D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites. Eur.J.Pharmacol. 128 303 PMID: 3025000
Fraser et al (2000) Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat. J.Pharmacol.Exp.Ther. 295 1135 PMID: 11082450
If you know of a relevant reference for DPDPE, please let us know.
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Keywords: DPDPE, supplier, Selective, agonists, δ-opioid, delta-opioid, d-opioid, DOP, Receptors, OP1, delta-receptor, [D-Pen2,5]Enkephalin, [D-Pen2,D-Pen5]Enkephalin, Delta, Opioid, Receptors, Delta, Opioid, Receptors, Tocris Bioscience
3 Citations for DPDPE
Citations are publications that use Tocris products. Selected citations for DPDPE include:
Saloman et al (2011) Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats. Am J Physiol Heart Circ Physiol 190 379 PMID: 21664434
Leal et al (2013) Peripheral δ-opioid receptors attenuate the exercise pressor reflex. PLoS One 305 H1246 PMID: 23934854
Peart et al (2007) Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. J Mol Cell Cardiol 42 972 PMID: 17407780
Do you know of a great paper that uses DPDPE from Tocris? If so please let us know.
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