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Biological Activity for Z-DEVD-FMK Caspase-3 Inhibitor
Z-DEVD-FMK Caspase-3 Inhibitor is a cell-permeable, irreversible inhibitor of caspase-3/CPP32. It inhibits tumor cell apoptosis. In vivo, it has a neuroprotective effect in rat hippocampus following seizures. It also significantly reduces post-traumatic apoptosis, and improved neurological recovery, before and after induced traumatic brain injury in rat.
Technical Data for Z-DEVD-FMK Caspase-3 Inhibitor
(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = DL-Asp(OMe)-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Z-DEVD-FMK Caspase-3 Inhibitor
|Solubility||Soluble to 1 mg/ml in DMSO|
Product Datasheets for Z-DEVD-FMK Caspase-3 Inhibitor
References for Z-DEVD-FMK Caspase-3 Inhibitor
References are publications that support the biological activity of the product.
Brocksted et al (1998) Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 273 28057 PMID: 9774422
Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 74 1215 PMID: 10693954
Kugawa et al (2000) Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 23 930 PMID: 10963298
Yakovlev et al (1997) Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J.Neurosci. 17 7415 PMID: 9295387
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Keywords: Z-DEVD-FMK Caspase-3 Inhibitor, Z-DEVD-FMK Caspase-3 Inhibitor supplier, cell-permeable, irreversible, caspase-3, inhibitors, inhibits, caspases, proteinases, proteases, in, vivo, apoptosis, neuroprotective, brain, injury, Caspases, 8009, Tocris Bioscience
Citations for Z-DEVD-FMK Caspase-3 Inhibitor
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Literature in this Area
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