Ac-FLTD-CMK

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Cat.No. 7242 - Ac-FLTD-CMK | Ac-Phe-Leu-Thr-Asp-CMK | CAS No. 2376255-48-8
Description: Potent and selective inhibitor of caspases 1, 5 and 4
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (7)

Biological Activity for Ac-FLTD-CMK

Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values = 46.7 nM, 0.33 μM, 1.49 μM, respectively), and inhibits murine caspase-11 at 10 μM. Ac-FLTD-CMK inhibits cleavage of gasdermin D by caspases, suppresses pyroptosis and reduces IL-1β release in macrophages.

Technical Data for Ac-FLTD-CMK

M. Wt 569.05
Formula C26H37ClN4O8
Sequence FLTD

(Modifications: Phe-1 = Ac-Phe, Asp-4 = Asp-CMK)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2376255-48-8
PubChem ID 155906572
InChI Key UCWNTWGHVCSMJP-WPUDHWPRSA-N
Smiles O=C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)[C@H](CC1=CC=CC=C1)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ac-FLTD-CMK

Solubility Soluble to 1 mg/ml in DMSO

References for Ac-FLTD-CMK

References are publications that support the biological activity of the product.

Yang et al (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc.Natl.Acad.Sci.U.S.A. 115 6792 PMID: 29891674


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Keywords: Ac-FLTD-CMK, Ac-FLTD-CMK supplier, AcFLTDCMK, potent, selective, inhibitors, inhibits, caspases, inflammasome, pyroptosis, IL-b, IL-beta, caspase1, Caspases, 7242, Tocris Bioscience

Citations for Ac-FLTD-CMK

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Literature in this Area

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