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Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values = 46.7 nM, 0.33 μM, 1.49 μM, respectively), and inhibits murine caspase-11 at 10 μM. Ac-FLTD-CMK inhibits cleavage of gasdermin D by caspases, suppresses pyroptosis and reduces IL-1β release in macrophages.
(Modifications: Phe-1 = Ac-Phe, Asp-4 = Asp-CMK)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in DMSO|
References are publications that support the biological activity of the product.
Yang et al (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc.Natl.Acad.Sci.U.S.A. 115 6792 PMID: 29891674
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Keywords: Ac-FLTD-CMK, Ac-FLTD-CMK supplier, AcFLTDCMK, potent, selective, inhibitors, inhibits, caspases, inflammasome, pyroptosis, IL-b, IL-beta, caspase1, Caspases, 7242, Tocris Bioscience
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