VX 765

Pricing Availability   Qty
Description: High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable
Alternative Names: Belnacasan
Chemical Name: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for VX 765

VX 765 is a high affinity and selective caspase-4 and caspase 1/ICE inhibitor (Ki of <0.6 and 0.8 nM, respectively). Prodrug of VRT-043198. Inhibits LPS-induced IL-1β production ~ 60% in collagen-induced arthritis mouse model. Exhibits anticonvulsant effects in mouse model of acute seizures. Anti-inflammatory. Orally bioavailable.

Compound Libraries for VX 765

VX 765 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VX 765

M. Wt 509
Formula C24H33ClN4O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 273404-37-8
PubChem ID 11398092
Smiles CCO[C@@H]1OC(C[C@@H]1NC([C@@H]2CCCN2C([C@H](C(C)(C)C)NC(C3=CC(Cl)=C(C=C3)N)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VX 765

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.9 100
ethanol 50.9 100

Preparing Stock Solutions for VX 765

The following data is based on the product molecular weight 509. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.82 mL 19.65 mL
5 mM 0.39 mL 1.96 mL 3.93 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Keywords: VX 765, VX 765 supplier, VX765, high, affinity, selective, caspase4, caspase1, inhibitors, inhibits, anticonvulsant, anti-inflammatory, orally, bioavailable, IL-converting, enzyme, ICE, Belnacasan, Caspases, 7143, Tocris Bioscience

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Literature in this Area

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