INF 4E

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Cat.No. 6172 - INF 4E | C12H13ClO3 | CAS No. 88039-46-7
Description: Caspase-1 and NLRP3 inflammasome inhibitor
Chemical Name: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.

Technical Data

M. Wt 240.68
Formula C12H13ClO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 88039-46-7
PubChem ID 11402215
InChI Key BSRPDXCMAOIUOO-UHFFFAOYSA-N
Smiles CCOC(C(C(C1=C(C=CC=C1)Cl)O)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

References

References are publications that support the biological activity of the product.

Cocco et al (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 57 10366 PMID: 25418070


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Keywords: INF 4E, INF 4E supplier, INF4E, NLRP3, inflammasomes, caspases, 1, inhibitors, inhibits, pyroptosis, nrf2, Caspases, Inflammasomes, Nrf2, 6172, Tocris Bioscience

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Literature in this Area

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