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Cat.No. 6172 - INF 4E | C12H13ClO3 | CAS No. 88039-46-7
Description: Caspase-1 and NLRP3 inflammasome inhibitor
Chemical Name: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
Purity: ≥98% (HPLC)

Biological Activity

NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.

Technical Data

M. Wt 240.68
Formula C12H13ClO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 88039-46-7
PubChem ID 11402215
Smiles CCOC(C(C(C1=C(C=CC=C1)Cl)O)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 240.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.15 mL 20.77 mL 41.55 mL
5 mM 0.83 mL 4.15 mL 8.31 mL
10 mM 0.42 mL 2.08 mL 4.15 mL
50 mM 0.08 mL 0.42 mL 0.83 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Cocco et al (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 57 10366 PMID: 25418070

If you know of a relevant reference for INF 4E, please let us know.

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Keywords: INF 4E, supplier, INF4E, NLRP3, inflammasomes, caspases, 1, inhibitors, inhibits, pyroptosis, nrf2, Caspases, Inflammasomes, Nrf2, Caspases, Tocris Bioscience

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