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NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)|
References are publications that support the biological activity of the product.
Cocco et al (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 57 10366 PMID: 25418070
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Keywords: INF 4E, INF 4E supplier, INF4E, NLRP3, inflammasomes, caspases, 1, inhibitors, inhibits, pyroptosis, nrf2, Caspases, Inflammasomes, Nrf2, 6172, Tocris Bioscience
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We used this product to study whether bacterial component can induce NLRP3-mediated IL-1beta production. To confirm whether this inhibitor works well, we pretreated THP-1 cells with the inhibitor for 1 h, followed by treatment with LPS+ATP for 2 h. The production of IL-1b in culture supernatant was measured by IL-1b ELISA kit. We showed that this inhibitor can significantly inhibit LPS/ATP-induced IL-1b production.
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