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KN 93 phosphate
CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 599.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||16.69 mL||83.47 mL||166.94 mL|
|0.5 mM||3.34 mL||16.69 mL||33.39 mL|
|1 mM||1.67 mL||8.35 mL||16.69 mL|
|5 mM||0.33 mL||1.67 mL||3.34 mL|
References are publications that support the biological activity of the product.
Anderson et al (1998) KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 287 996 PMID: 9864285
Sumi et al (1991) The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm. 181 968 PMID: 1662507
Rezazadeh et al (2006) KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898
Bruno et al (2010) Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II. Synthesis 24 4193
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Keywords: KN 93 phosphate, KN 93 phosphate supplier, KN93, phosphate, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Protein, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, inhibitors, inhibits, water, soluble, 5215, Tocris Bioscience
2 Citations for KN 93 phosphate
Citations are publications that use Tocris products. Selected citations for KN 93 phosphate include:
Zhang et al (2018) Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models. Nat Commun 9 4272 PMID: 30323233
Mauger et al (2016) Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity. Neuron 92 1266 PMID: 28009274
Do you know of a great paper that uses KN 93 phosphate from Tocris? Please let us know.
Reviews for KN 93 phosphate
Average Rating: 5 (Based on 1 Review.)
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Guinea pig ventricular cardiomyocytes were incubated with KN93 phosphate (5 µM, 30 min) prior to HOCl-LDL (250 µg/ml, 14 h) addition followed by loading of cells with Fura-2AM. Cells were stimulated at a 1 Hz frequency and Ca2+ transient (CaT) amplitude was analyzed. KN93 phosphate significantly inhibited HOCl-LDL-reduced CaT amplitude
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