KN 93 phosphate

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Description: CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)
Chemical Name: N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate
Purity: ≥98% (HPLC)
Citations (5)
Reviews (1)

Biological Activity for KN 93 phosphate

KN 93 phosphate is a CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).

Technical Data for KN 93 phosphate

M. Wt 599.03
Formula C26H29ClN2O4S.H3PO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1188890-41-6
PubChem ID 16760530
Smiles O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O.O=P(O)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KN 93 phosphate

Solvent Max Conc. mg/mL Max Conc. mM
water 5.99 10

Preparing Stock Solutions for KN 93 phosphate

The following data is based on the product molecular weight 599.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.69 mL 83.47 mL 166.94 mL
0.5 mM 3.34 mL 16.69 mL 33.39 mL
1 mM 1.67 mL 8.35 mL 16.69 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

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Product Datasheets for KN 93 phosphate

Certificate of Analysis / Product Datasheet
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References for KN 93 phosphate

References are publications that support the biological activity of the product.

Anderson et al (1998) KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 287 996 PMID: 9864285

Sumi et al (1991) The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm. 181 968 PMID: 1662507

Rezazadeh et al (2006) KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898

Bruno et al (2010) Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II. Synthesis 24 4193

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Keywords: KN 93 phosphate, KN 93 phosphate supplier, KN93, phosphate, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Protein, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, inhibitors, inhibits, water, soluble, 5215, Tocris Bioscience

5 Citations for KN 93 phosphate

Citations are publications that use Tocris products. Selected citations for KN 93 phosphate include:

Fading et al (2017) Synaptic activity suppresses expression of neurogenic differentiation factor 2 in an NMDA receptor-dependent manner. Synapse 71 PMID: 28524267

Mark et al (2013) Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A 110 E1026-34 PMID: 23431153

Kurt F et al (2019) Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions. J Neurochem 149 98-110 PMID: 30674062

Mauger et al (2016) Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity. Neuron 92 1266 PMID: 28009274

Do you know of a great paper that uses KN 93 phosphate from Tocris? Please let us know.

Reviews for KN 93 phosphate

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KN93 phosphate inhibits HOCl-LDL-reduced Ca2+ transient amplitude in cardiomyocytes.
By Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Cardiomyocytes

Guinea pig ventricular cardiomyocytes were incubated with KN93 phosphate (5 µM, 30 min) prior to HOCl-LDL (250 µg/ml, 14 h) addition followed by loading of cells with Fura-2AM. Cells were stimulated at a 1 Hz frequency and Ca2+ transient (CaT) amplitude was analyzed. KN93 phosphate significantly inhibited HOCl-LDL-reduced CaT amplitude

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