Inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 289.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||34.57 mL||172.84 mL||345.67 mL|
|0.5 mM||6.91 mL||34.57 mL||69.13 mL|
|1 mM||3.46 mL||17.28 mL||34.57 mL|
|5 mM||0.69 mL||3.46 mL||6.91 mL|
References are publications that support the biological activity of the product.
Chen et al (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 286 43951 PMID: 22020937
If you know of a relevant reference for A 484954, please let us know.
View Related Products by Product Action
Keywords: A 484954, A 484954 supplier, A484954, eukaryotic, elongation, factor-2, kinase, eef2k, inhibitors, inhibits, CaM, Kinase, 4483, Tocris Bioscience
Citations for A 484954
Citations are publications that use Tocris products.
Currently there are no citations for A 484954. Do you know of a great paper that uses A 484954 from Tocris? Please let us know.
Reviews for A 484954
There are currently no reviews for this product. Be the first to review A 484954 and earn rewards!
Have you used A 484954?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.