CS 640

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent CaM kinase I inhibitor
Chemical Name: 2-[(3S)-3-Amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]-5-pyrimidinecarboxamide
Purity: ≥98% (HPLC)

Biological Activity for CS 640

CS 640 is a potent calmodulin-dependent kinase I (CaMKI) inhibitor (IC50 values are 1 nM, 1 nM, 3 nM and 8 nM at CAMK1A, CAMK1G, CAMK1B and CAMK1D respectively). Improves insulin sensitivity and glucose control in a mouse model of diet-induced obesity. Orally bioavailable in rodents.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the CS 640 probe summary on the SGC website.

Technical Data for CS 640

M. Wt 397.53
Formula C21H31N7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2388506-83-8
PubChem ID 145946080
Smiles NC(C1=CN=C(N2C[C@H](CCC2)N)N=C1NC3=CC(C(C)C)=NC(C(C)C)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CS 640

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.95 20
ethanol 3.98 10

Preparing Stock Solutions for CS 640

The following data is based on the product molecular weight 397.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.58 mL 62.89 mL 125.78 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
2 mM 1.26 mL 6.29 mL 12.58 mL
10 mM 0.25 mL 1.26 mL 2.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for CS 640

References are publications that support the biological activity of the product.

Fromont et al (2020) Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obesity in vivo mouse model. J.Med.Chem. 63 6784 PMID: 32433887

If you know of a relevant reference for CS 640, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Calmodulin-Dependent Kinase Inhibitors

Keywords: CS 640, CS 640 supplier, CS640, calmodulin, dependent, kinase, inhibitors, inhibitor, inhibit, inhibits, CAMK, potent, insulin, obesity, glucose, CaM, Kinase, 7982, Tocris Bioscience

Citations for CS 640

Citations are publications that use Tocris products.

Currently there are no citations for CS 640. Do you know of a great paper that uses CS 640 from Tocris? Please let us know.

Reviews for CS 640

There are currently no reviews for this product. Be the first to review CS 640 and earn rewards!

Have you used CS 640?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review