CS 640

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Description: Potent CaM kinase I inhibitor
Chemical Name: 2-[(3S)-3-Amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]-5-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for CS 640

CS 640 is a potent calmodulin-dependent kinase I (CaMKI) inhibitor (IC50 values are 1 nM, 1 nM, 3 nM and 8 nM at CAMK1A, CAMK1G, CAMK1B and CAMK1D respectively). Improves insulin sensitivity and glucose control in a mouse model of diet-induced obesity. Orally bioavailable in rodents.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the CS 640 probe summary on the SGC website.

Technical Data for CS 640

M. Wt 397.53
Formula C21H31N7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2388506-83-8
PubChem ID 145946080
InChI Key BWBUPDTUXQDHSX-AWEZNQCLSA-N
Smiles NC(C1=CN=C(N2C[C@H](CCC2)N)N=C1NC3=CC(C(C)C)=NC(C(C)C)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CS 640

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.95 20
ethanol 3.98 10

Preparing Stock Solutions for CS 640

The following data is based on the product molecular weight 397.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.58 mL 62.89 mL 125.78 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
2 mM 1.26 mL 6.29 mL 12.58 mL
10 mM 0.25 mL 1.26 mL 2.52 mL

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References for CS 640

References are publications that support the biological activity of the product.

Fromont et al (2020) Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obesity in vivo mouse model. J.Med.Chem. 63 6784 PMID: 32433887


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Citations for CS 640

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