Calcium-activated Chloride Channels

Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin.

Products
Background
Literature
Pathways
Gene Data

Activators

Cat No Product Name / Activity
4876 Eact
Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)

Blockers

Cat No Product Name / Activity
6076 Ani 9
Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker
5420 Benzbromarone
TMEM16A/B calcium-activated chloride channel (CaCC) blocker
4877 CaCCinh-A01
Calcium-activated chloride channel (CaCC) inhibitor
4522 Flufenamic acid
Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
5770 MONNA
Potent TMEM16A (Anoctamin-1) blocker
0593 NPPB
Inhibits calcium-sensitive chloride currents
4538 T16Ainh - A01
Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor
2510 Talniflumate
CaCC blocker and Cl-/HCO3- exchange inhibitor

Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin. The molecular nature of CaCC is unresolved; the CLCA, BEST and TMEM16 (anoctamin) genes have all been proposed as potential molecular candidates for the channel, although it is now generally considered that CLCA proteins do not form ion channels.

CaCC have a variety of roles: in transepithelial salt transport; excitability in neurons, skeletal, cardiac and smooth muscle cells; acidification; cell cycle; oocyte fertilization; and apoptosis. They also play an important role in the cardiovascular system through control of cell proliferation and vascular remodeling during hypertension, regulation of smooth muscle tone and cardiac action potential repolarization in some species. TMEM16A has also been found in sensory neurons localized with nociceptor markers, suggesting it may also play a role in nociception.

Literature for Calcium-activated Chloride Channels

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Calcium-activated Chloride Channels

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Calcium-activated chloride channel Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Anoctamin 1 Human ANO1 NM_018043 Q5XXA6
Mouse Ano1 NM_178642 Q8BHY3
Rat Ano1 NM_001107564 NP_001101034
Anoctamin 2 Human ANO2 NM_020373 Q9NQ90
Mouse Ano2 NM_153589 Q8CFW1
Rat Ano2 - -
Anoctamin 3 Human ANO3 NM_031418 Q9BYT9
Mouse Ano3 NM_001128103 NP_001121575
Rat Ano3 - -
Anoctamin 4 Human ANO4 NM_178826 Q32M45
Mouse Ano4 NM_178773 Q8C5H1
Rat Ano4 NM_001106778 NP_001100248
Anoctamin 5 Human ANO5 NM_213599 Q75V66
Mouse Ano5 NM_177694 Q75UR0
Rat Ano5 - -
Anoctamin 6 Human ANO6 NM_001025356 Q4KMQ2
Mouse Ano6 NM_001253813 Q6P9J9
Rat Ano6 NM_001108108 NP_001101578
Anoctamin 7 Human ANO7 NM_001001891 Q6IWH7
Mouse Ano7 NM_207031 Q14AT5
Rat Ano7 NM_001004071 NP_001004071
Anoctamin 8 Human ANO8 NM_020959 Q9HCE9
Mouse Ano8 NM_001164679 Q6PB70
Rat Ano8 - -
Anoctamin 9 Human ANO9 NM_001012302 A1A5B4
Mouse Ano9 NM_178381 P86044
Rat Ano9 - -
Anoctamin 10 Human ANO10 NM_018075 Q9NW15
Mouse Ano10 NM_133979 Q8BH79
Rat Ano10 - -
Bestrophin 1 Human BEST1 NM_004183 O76090
Mouse Best1 NM_011913 O88870
Rat Best1 NM_001011940 NP_001011940
Bestrophin 2 Human BEST2 NM_017682 Q8NFU1
Mouse Best2 NR_052011 Q8BGM5
Rat Best2 NM_001108895 NP_001102365
Bestrophin 3 Human BEST3 NM_152439 Q8N1M1
Mouse Best3 NM_001007583 Q6H1V1
Rat Best3 NM_001191783 NP_001178712
Bestrophin 4 Human BEST4 NM_153274 Q8NFU0
Mouse - - -
Rat Best4 - -