Calcium-activated Chloride Channels

Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin. The molecular nature of CaCC is unresolved; the CLCA, BEST and TMEM16 (anoctamin) genes have all been proposed as potential molecular candidates for the channel, although it is now generally considered that CLCA proteins do not form ion channels.

CaCC have a variety of roles: in transepithelial salt transport; excitability in neurons, skeletal, cardiac and smooth muscle cells; acidification; cell cycle; oocyte fertilization; and apoptosis. They also play an important role in the cardiovascular system through control of cell proliferation and vascular remodeling during hypertension, regulation of smooth muscle tone and cardiac action potential repolarization in some species. TMEM16A has also been found in sensory neurons localized with nociceptor markers, suggesting it may also play a role in nociception.

External sources of pharmacological information for Calcium-activated Chloride Channels :

• BJP Guide

Literature for Calcium-activated Chloride Channels

Tocris offers the following scientific literature for Calcium-activated Chloride Channels to showcase our products. We invite you to request* your copy today!

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Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

• Hypertension
• Thrombosis and Hemostasis
• Atherosclerosis
• Myocardial Infarction
• Ischemia/Reperfusion Injury
• Arrhythmias
• Heart Failure

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Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

• Ligand-gated ion channels
• Voltage-gated ion channels
• Other Ion Channels

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Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

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Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

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Pathways for Calcium-activated Chloride Channels

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

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Calcium-activated chloride channel Gene Data