Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin.
Calcium-activated Chloride Channel Activators |
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Cat. No. | Product Name / Activity |
4876 | Eact |
Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) | |
Calcium-activated Chloride Channel Blockers |
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Cat. No. | Product Name / Activity |
6076 | Ani 9 |
Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker | |
4877 | CaCCinh-A01 |
Calcium-activated chloride channel (CaCC) inhibitor | |
4522 | Flufenamic acid |
Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6 | |
5770 | MONNA |
Potent TMEM16A (Anoctamin-1) blocker | |
4079 | Niclosamide |
TMEM16F inhibitor; also STAT3 inhibitor | |
0593 | NPPB |
Inhibits calcium-sensitive chloride currents | |
4538 | T16Ainh - A01 |
Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor | |
Other |
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Cat. No. | Product Name / Activity |
5948 | DMNPE-4 AM-caged-calcium |
Caged calcium; cell permeable |
Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin. The molecular nature of CaCC is unresolved; the CLCA, BEST and TMEM16 (anoctamin) genes have all been proposed as potential molecular candidates for the channel, although it is now generally considered that CLCA proteins do not form ion channels.
CaCC have a variety of roles: in transepithelial salt transport; excitability in neurons, skeletal, cardiac and smooth muscle cells; acidification; cell cycle; oocyte fertilization; and apoptosis. They also play an important role in the cardiovascular system through control of cell proliferation and vascular remodeling during hypertension, regulation of smooth muscle tone and cardiac action potential repolarization in some species. TMEM16A has also been found in sensory neurons localized with nociceptor markers, suggesting it may also play a role in nociception.
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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Anoctamin 1 | Human | ANO1 | NM_018043 | Q5XXA6 |
Mouse | Ano1 | NM_178642 | Q8BHY3 | |
Rat | Ano1 | NM_001107564 | NP_001101034 | |
Anoctamin 2 | Human | ANO2 | NM_020373 | Q9NQ90 |
Mouse | Ano2 | NM_153589 | Q8CFW1 | |
Rat | Ano2 | - | - | |
Anoctamin 3 | Human | ANO3 | NM_031418 | Q9BYT9 |
Mouse | Ano3 | NM_001128103 | NP_001121575 | |
Rat | Ano3 | - | - | |
Anoctamin 4 | Human | ANO4 | NM_178826 | Q32M45 |
Mouse | Ano4 | NM_178773 | Q8C5H1 | |
Rat | Ano4 | NM_001106778 | NP_001100248 | |
Anoctamin 5 | Human | ANO5 | NM_213599 | Q75V66 |
Mouse | Ano5 | NM_177694 | Q75UR0 | |
Rat | Ano5 | - | - | |
Anoctamin 6 | Human | ANO6 | NM_001025356 | Q4KMQ2 |
Mouse | Ano6 | NM_001253813 | Q6P9J9 | |
Rat | Ano6 | NM_001108108 | NP_001101578 | |
Anoctamin 7 | Human | ANO7 | NM_001001891 | Q6IWH7 |
Mouse | Ano7 | NM_207031 | Q14AT5 | |
Rat | Ano7 | NM_001004071 | NP_001004071 | |
Anoctamin 8 | Human | ANO8 | NM_020959 | Q9HCE9 |
Mouse | Ano8 | NM_001164679 | Q6PB70 | |
Rat | Ano8 | - | - | |
Anoctamin 9 | Human | ANO9 | NM_001012302 | A1A5B4 |
Mouse | Ano9 | NM_178381 | P86044 | |
Rat | Ano9 | - | - | |
Anoctamin 10 | Human | ANO10 | NM_018075 | Q9NW15 |
Mouse | Ano10 | NM_133979 | Q8BH79 | |
Rat | Ano10 | - | - | |
Bestrophin 1 | Human | BEST1 | NM_004183 | O76090 |
Mouse | Best1 | NM_011913 | O88870 | |
Rat | Best1 | NM_001011940 | NP_001011940 | |
Bestrophin 2 | Human | BEST2 | NM_017682 | Q8NFU1 |
Mouse | Best2 | NR_052011 | Q8BGM5 | |
Rat | Best2 | NM_001108895 | NP_001102365 | |
Bestrophin 3 | Human | BEST3 | NM_152439 | Q8N1M1 |
Mouse | Best3 | NM_001007583 | Q6H1V1 | |
Rat | Best3 | NM_001191783 | NP_001178712 | |
Bestrophin 4 | Human | BEST4 | NM_153274 | Q8NFU0 |
Mouse | - | - | - | |
Rat | Best4 | - | - |