DMNPE-4 AM-caged-calcium

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Calcium cage; cell permeable
Chemical Name: Bis(acetoxymethyl) 3,12-bis(2-(acetoxymethoxy)-2-oxoethyl)-5-(4,5-dimethoxy-2-nitrophenyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioate
Purity: ≥95% (HPLC)

Biological Activity for DMNPE-4 AM-caged-calcium

DMNPE-4 AM-caged-calcium is a calcium cage. In the presence of calcium, the compound will chelate and cage calcium (Kd values are 48 and 19 nM at pH 7.2 and 7.4, respectively; Kd after uncaging = 2 mM). DMNPE-4 AM-caged-calcium is selective for Ca2+ over Mg2+ (Kd = 10 mM). Rapid and efficient calcium release occurs upon photolysis at 350 nm. It can also be used for two-photon uncaging. Extinction coefficient of 5120 M-1 cm-1, quantum yield 0.09. Cell permeable.

Technical Data for DMNPE-4 AM-caged-calcium

M. Wt 849.74
Formula C34H47N3O22
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2253744-58-8
PubChem ID 137919855

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DMNPE-4 AM-caged-calcium

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 84.97 100

Preparing Stock Solutions for DMNPE-4 AM-caged-calcium

The following data is based on the product molecular weight 849.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.18 mL 5.88 mL 11.77 mL
5 mM 0.24 mL 1.18 mL 2.35 mL
10 mM 0.12 mL 0.59 mL 1.18 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for DMNPE-4 AM-caged-calcium

References for DMNPE-4 AM-caged-calcium

References are publications that support the biological activity of the product.

Wang et al (2015) Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells Cell 163 1348 PMID: 26627734

Gordon et al (2008) Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature 456 745 PMID: 18971930

Ellis-Davies et al (2006) Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties. Cell Calcium 39 75 PMID: 16303177

If you know of a relevant reference for DMNPE-4 AM-caged-calcium, please let us know.

Keywords: DMNPE-4 AM-caged-calcium, DMNPE-4 AM-caged-calcium supplier, Caged, calcium, cell, permeable, rapid, photolysis, Second, Messenger, Compounds, Ca2+-Activated, Chloride, Channels, Non-selective, Cav, Potassium, General, Calcium, Signaling, Agents, 5948, Tocris Bioscience

Citations for DMNPE-4 AM-caged-calcium

Citations are publications that use Tocris products.

Currently there are no citations for DMNPE-4 AM-caged-calcium. Do you know of a great paper that uses DMNPE-4 AM-caged-calcium from Tocris? Please let us know.

Reviews for DMNPE-4 AM-caged-calcium

There are currently no reviews for this product. Be the first to review DMNPE-4 AM-caged-calcium and earn rewards!

Have you used DMNPE-4 AM-caged-calcium?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review