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Submit ReviewDMNPE-4 AM-caged-calcium
Discontinued Product
5948 has been discontinued.
View all Caged Second Messenger Compounds products.
Description: Calcium cage; cell permeable
Chemical Name: Bis(acetoxymethyl) 3,12-bis(2-(acetoxymethoxy)-2-oxoethyl)-5-(4,5-dimethoxy-2-nitrophenyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioate
Purity: ≥90% (HPLC)
Biological Activity for DMNPE-4 AM-caged-calcium
DMNPE-4 AM-caged-calcium is a calcium cage. In the presence of calcium, the compound will chelate and cage calcium (Kd values are 48 and 19 nM at pH 7.2 and 7.4, respectively; Kd after uncaging = 2 mM). DMNPE-4 AM-caged-calcium is selective for Ca2+ over Mg2+ (Kd = 10 mM). Rapid and efficient calcium release occurs upon photolysis at 350 nm. It can also be used for two-photon uncaging. Extinction coefficient of 5120 M-1 cm-1, quantum yield 0.09. Cell permeable.
Technical Data for DMNPE-4 AM-caged-calcium
| M. Wt | 849.74 |
| Formula | C34H47N3O22 |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 2253744-58-8 |
| PubChem ID | 137919855 |
| InChI Key | UUZFENOXYOBVDU-UHFFFAOYSA-N |
| Smiles | O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)CCOCCOC(CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(C=C1OC)=C(C=C1OC)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DMNPE-4 AM-caged-calcium
References for DMNPE-4 AM-caged-calcium
References are publications that support the biological activity of the product.
Wang et al (2015) Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells Cell 163 1348 PMID: 26627734
Gordon et al (2008) Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature 456 745 PMID: 18971930
Ellis-Davies et al (2006) Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties. Cell Calcium 39 75 PMID: 16303177
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Citations for DMNPE-4 AM-caged-calcium
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