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Description: Potent TMEM16A (Anoctamin-1) blocker
Chemical Name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)
Pathways (1)

Biological Activity for MONNA

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.

Technical Data for MONNA

M. Wt 338.31
Formula C18H14N2O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1572936-83-4
PubChem ID 72165188
Smiles COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MONNA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.83 100

Preparing Stock Solutions for MONNA

The following data is based on the product molecular weight 338.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.56 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References for MONNA

References are publications that support the biological activity of the product.

Oh et al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726 PMID: 23997117

Boedtkjer et al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158 PMID: 26013995

Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells. Eur.J.Pharmacol. PMID: 36967079

If you know of a relevant reference for MONNA, please let us know.

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Keywords: MONNA, MONNA supplier, CaCC, TMEM16A, blockers, blocks, calcium-activated, chloride, channels, anoctamin-1, ANO1, potent, Ca2+-Activated, Chloride, Channels, 5770, Tocris Bioscience

2 Citations for MONNA

Citations are publications that use Tocris products. Selected citations for MONNA include:

Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079

Armen et al (2022) Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine. Br J Pharmacol 179 1187-1200 PMID: 34519057

Do you know of a great paper that uses MONNA from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for MONNA

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.