MONNA
Biological Activity
Potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
Technical Data
| M. Wt | 338.31 |
| Formula | C18H14N2O5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1572936-83-4 |
| PubChem ID | 72165188 |
| InChI Key | JIVRLHBAUUZTNC-UHFFFAOYSA-N |
| Smiles | COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 338.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.78 mL | 29.56 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Oh et al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726 PMID: 23997117
Boedtkjer et al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158 PMID: 26013995
If you know of a relevant reference for MONNA, please let us know.
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Keywords: CaCC TMEM16A blockers blocks calcium-activated chloride channels anoctamin-1 ANO1 potent Ca2+-Activated Chloride Channels
Citations for MONNA
Citations are publications that use Tocris products.
Currently there are no citations for MONNA. Do you know of a great paper that uses MONNA from Tocris? If so please let us know.
Literature in this Area
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
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- Atherosclerosis
- Myocardial Infarction
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for MONNA
