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Description: Potent TMEM16A (Anoctamin-1) blocker
Chemical Name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for MONNA
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.
Technical Data for MONNA
| M. Wt | 338.31 |
| Formula | C18H14N2O5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1572936-83-4 |
| PubChem ID | 72165188 |
| InChI Key | JIVRLHBAUUZTNC-UHFFFAOYSA-N |
| Smiles | COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MONNA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.83 | 100 |
Preparing Stock Solutions for MONNA
The following data is based on the product molecular weight 338.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.78 mL | 29.56 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for MONNA
References for MONNA
References are publications that support the biological activity of the product.
Oh et al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726 PMID: 23997117
Boedtkjer et al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158 PMID: 26013995
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells. Eur.J.Pharmacol. PMID: 36967079
If you know of a relevant reference for MONNA, please let us know.
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Keywords: MONNA, MONNA supplier, CaCC, TMEM16A, blockers, blocks, calcium-activated, chloride, channels, anoctamin-1, ANO1, potent, Ca2+-Activated, Chloride, Channels, 5770, Tocris Bioscience
1 Citation for MONNA
Citations are publications that use Tocris products. Selected citations for MONNA include:
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079
Do you know of a great paper that uses MONNA from Tocris? Please let us know.
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