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MONNA

Cat. No. 5770 Submit a Review Datasheet / COA / SDS
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Cat.No. 5770 - MONNA | C18H14N2O5 | CAS No. 1572936-83-4
Description: Potent TMEM16A (Anoctamin-1) blocker
Chemical Name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.

Technical Data

M. Wt 338.31
Formula C18H14N2O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1572936-83-4
PubChem ID 72165188
InChI Key JIVRLHBAUUZTNC-UHFFFAOYSA-N
Smiles COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 338.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.56 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Oh et al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726 PMID: 23997117

Boedtkjer et al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158 PMID: 26013995

If you know of a relevant reference for MONNA, please let us know.

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Citations for MONNA

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Literature in this Area

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