MONNA

Cat. No. 5770 Submit a Review Datasheet / COA / SDS

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Cat.No. 5770 - MONNA | C18H14N2O5 | CAS No. 1572936-83-4

Description: Potent TMEM16A (Anoctamin-1) blocker

Chemical Name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (4)

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MONNA

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC₅₀ = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.

Technical Data for MONNA

M. Wt	338.31
Formula	C₁₈H₁₄N₂O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1572936-83-4
PubChem ID	72165188
InChI Key	JIVRLHBAUUZTNC-UHFFFAOYSA-N
Smiles	COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MONNA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.83	100

Preparing Stock Solutions for MONNA

The following data is based on the product molecular weight 338.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.56 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.3 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

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Product Datasheets for MONNA

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for MONNA

References are publications that support the biological activity of the product.

Oh et al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726 PMID: 23997117

Boedtkjer et al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158 PMID: 26013995

If you know of a relevant reference for MONNA, please let us know.

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Keywords: MONNA, MONNA supplier, CaCC, TMEM16A, blockers, blocks, calcium-activated, chloride, channels, anoctamin-1, ANO1, potent, Ca2+-Activated, Chloride, Channels, 5770, Tocris Bioscience

Citations for MONNA

Citations are publications that use Tocris products.

Currently there are no citations for MONNA. Do you know of a great paper that uses MONNA from Tocris? Please let us know.

Reviews for MONNA

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

Hypertension
Thrombosis and Hemostasis
Atherosclerosis
Myocardial Infarction
Ischemia/Reperfusion Injury
Arrhythmias
Heart Failure

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

Ligand-gated ion channels
Voltage-gated ion channels
Other Ion Channels

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for MONNA

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.