Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.
M. Wt | 338.31 |
Formula | C18H14N2O5 |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 1572936-83-4 |
PubChem ID | 72165188 |
InChI Key | JIVRLHBAUUZTNC-UHFFFAOYSA-N |
Smiles | COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 33.83 | 100 |
The following data is based on the product molecular weight 338.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.96 mL | 14.78 mL | 29.56 mL |
5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
References are publications that support the biological activity of the product.
Oh et al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726 PMID: 23997117
Boedtkjer et al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158 PMID: 26013995
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells. Eur.J.Pharmacol. PMID: 36967079
If you know of a relevant reference for MONNA, please let us know.
Keywords: MONNA, MONNA supplier, CaCC, TMEM16A, blockers, blocks, calcium-activated, chloride, channels, anoctamin-1, ANO1, potent, Ca2+-Activated, Chloride, Channels, 5770, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for MONNA include:
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079
Do you know of a great paper that uses MONNA from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review MONNA and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.