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Biological Activity for Ani 9
Ani 9 is a potent and selective TMEM16A (Anoctamin-1; ANO1) blocker (IC50 = 77 nM). Displays no effect on ANO2 activity (at 10 μM). Also exhibits no effect on intracellular calcium signaling or CFTR and ENaC channel activity (at 30 μM).
Technical Data for Ani 9
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ani 9
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ani 9
The following data is based on the product molecular weight 332.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3 mL||15.02 mL||30.05 mL|
|5 mM||0.6 mL||3 mL||6.01 mL|
|10 mM||0.3 mL||1.5 mL||3 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References for Ani 9
References are publications that support the biological activity of the product.
Seo et al (2016) Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 11 e0155771 PMID: 27219012
If you know of a relevant reference for Ani 9, please let us know.
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Keywords: Ani 9, Ani 9 supplier, Ani9, Potent, TMEM16A, Anoctamin-1, blockers, transmembrane, protein, 16A, CaCC, blocks, calcium-activated, chloride, channels, ANO1, Ca2+-Activated, Chloride, Channels, 6076, Tocris Bioscience
2 Citations for Ani 9
Citations are publications that use Tocris products. Selected citations for Ani 9 include:
Heikki et al (2021) ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma. Cancers (Basel) 13 PMID: 33803266
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079
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