Ani 9

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Cat.No. 6076 - Ani 9 | C17H17ClN2O3 | CAS No. 356102-14-2
Description: Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker
Chemical Name: 2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker (IC50 = 77 nM). Displays no effect on ANO2 activity (at 10 μM). Also exhibits no effect on intracellular calcium signaling or CFTR and ENaC channel activity (at 30 μM).

Technical Data

M. Wt 332.78
Formula C17H17ClN2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 356102-14-2
PubChem ID 9556542
InChI Key KDALDZRKOBJXIE-VXLYETTFSA-N
Smiles COC1=C(C=CC=C1)/C=N/NC(COC2=C(C=C(C=C2)Cl)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 332.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3 mL 15.02 mL 30.05 mL
5 mM 0.6 mL 3 mL 6.01 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Seo et al (2016) Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 11 e0155771 PMID: 27219012


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Citations for Ani 9

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cardiovascular

Cardiovascular Research Product Guide

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  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Ani 9

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.