Pricing Availability   Qty
Description: Calcium-activated chloride channel (CaCC) inhibitor
Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Purity: ≥99% (HPLC)
Citations (7)
Literature (1)
Pathways (1)

Biological Activity for CaCCinh-A01

CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).

Technical Data for CaCCinh-A01

M. Wt 347.43
Formula C18H21NO4S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 407587-33-1
PubChem ID 2898877
Smiles CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CaCCinh-A01

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.74 100
ethanol 3.47 10 with gentle warming

Preparing Stock Solutions for CaCCinh-A01

The following data is based on the product molecular weight 347.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets for CaCCinh-A01

Certificate of Analysis / Product Datasheet
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References for CaCCinh-A01

References are publications that support the biological activity of the product.

Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365 PMID: 21084298

De La Fuente et al (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 73 758 PMID: 18083779

If you know of a relevant reference for CaCCinh-A01, please let us know.

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Keywords: CaCCinh-A01, CaCCinh-A01 supplier, calcium-activated, chloride, channels, CaCC, inhibitors, inhibits, TMEM16A, Ca2+-Activated, Chloride, Channels, 4877, Tocris Bioscience

7 Citations for CaCCinh-A01

Citations are publications that use Tocris products. Selected citations for CaCCinh-A01 include:

Zaitseva et al (2017) Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine. Cell Host Microbe 22 99 PMID: 28704658

Armen et al (2022) Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine. Br J Pharmacol 179 1187-1200 PMID: 34519057

Kamran et al (2023) Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis. Nat Commun 14 616 PMID: 36739273

Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079

Do you know of a great paper that uses CaCCinh-A01 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for CaCCinh-A01

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.