CaCCinh-A01

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Cat.No. 4877 - CaCCinh-A01 | C18H21NO4S | CAS No. 407587-33-1
Description: Calcium-activated chloride channel (CaCC) inhibitor
Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).

Compound Libraries

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Technical Data

M. Wt 347.43
Formula C18H21NO4S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 407587-33-1
PubChem ID 2898877
InChI Key ACLUEOBQFRYTQS-UHFFFAOYSA-N
Smiles CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 3.47 10 with gentle warming
DMSO 34.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 347.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365 PMID: 21084298

De La Fuente et al (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 73 758 PMID: 18083779


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Keywords: CaCCinh-A01, CaCCinh-A01 supplier, calcium-activated, chloride, channels, CaCC, inhibitors, inhibits, TMEM16A, Ca2+-Activated, Chloride, Channels, 4877, Tocris Bioscience

1 Citation for CaCCinh-A01

Citations are publications that use Tocris products. Selected citations for CaCCinh-A01 include:

Amjad et al (2015) Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol 145 285 PMID: 25779870


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Pathways for CaCCinh-A01

Apoptosis

Apoptosis Signaling Pathway

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