Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.
Agonists |
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Cat No | Product Name / Activity |
3418 | Amylin |
Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors | |
6030 | Amylin (rat) |
Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors | |
6031 | Calcitonin (human) |
Endogenous calcitonin receptor agonist; inhibits bone resorption | |
1159 | Calcitonin (salmon) |
Affects bone formation and resorption | |
3012 | α-CGRP (human) |
CGRP receptor agonist | |
1161 | CGRP (rat) |
Potent vasodilator | |
3555 | CRSP-1 |
Endogenous central calcitonin receptor agonist | |
2080 | PHM 27 (human) |
Potent calcitonin receptor agonist; endogenous analog of human VIP | |
5031 | Pramlintide |
Synthetic version of amylin (Cat. No. 3418) | |
2550 | SUN-B 8155 |
Non-peptide calcitonin (CT) receptor agonist | |
Antagonists |
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Cat No | Product Name / Activity |
3419 | AC 187 |
Potent and selective amylin receptor antagonist | |
4561 | BIBN 4096 |
Potent and selective CGRP receptor antagonist | |
1181 | CGRP 8-37 (human) |
CGRP1 receptor antagonist | |
1169 | CGRP 8-37 (rat) |
CGRP1 receptor antagonist | |
4314 | SB 268262 |
Selective non-peptide CGRP1 antagonist |
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid.
The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main function is inducing vasodilation, which causes hypotension. The CGRP receptor has also recently been implicated in the pathogenesis of migraine
Tocris offers the following scientific literature for Calcitonin and Related Receptors to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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CT | Human | CALCR | NM_001742 | P30988 |
Mouse | Calcr | NM_007588 | Q60755 | |
Rat | Calcr | NM_053816 | P32214 | |
CALCRL | Human | CALCRL | NM_005795 | Q16602 |
Mouse | Calcrl | NM_018782 | Q9R1W5 | |
Rat | Calcrl | NM_012717 | Q63118 | |
RAMP1 | Human | RAMP1 | NM_005855 | O60894 |
Mouse | Ramp1 | NM_016894 | Q9WTJ5 | |
Rat | Ramp1 | NM_031645 | Q9JJ74 | |
RAMP2 | Human | RAMP2 | NM_005854 | O60895 |
Mouse | Ramp2 | NM_019444 | Q9WUP0 | |
Rat | Ramp2 | NM_031646 | Q9JHJ1 | |
RAMP3 | Human | RAMP3 | NM_005856 | O60896 |
Mouse | Ramp3 | NM_019511 | Q9WUP1 | |
Rat | Ramp3 | NM_020100 | Q9JJ73 |
CT and CALCRL form heterodimers with RAMP1-3, forming additional calcitonin related receptors; AMY1, AMY2, AMY3, CGRP, AM1 and AM2. (AMY1 = CT + RAMP1, AMY2 = CT + RAMP2, AMY3 = CT + RAMP3, CGRP = CALCRL + RAMP1, AM1 = CALCRL + RAMP2, AM2 = CALCRL + RAMP3)