Calcitonin and Related Receptors

Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3418 Amylin
Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors
6030 Amylin (rat)
Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors
6031 Calcitonin (human)
Endogenous calcitonin receptor agonist; inhibits bone resorption
1159 Calcitonin (salmon)
Affects bone formation and resorption
3012 α-CGRP (human)
CGRP receptor agonist
1161 CGRP (rat)
Potent vasodilator
3555 CRSP-1
Endogenous central calcitonin receptor agonist
2080 PHM 27 (human)
Potent calcitonin receptor agonist; endogenous analog of human VIP
5031 Pramlintide
Synthetic version of amylin (Cat. No. 3418)
2550 SUN-B 8155
Non-peptide calcitonin (CT) receptor agonist

Antagonists

Cat No Product Name / Activity
3419 AC 187
Potent and selective amylin receptor antagonist
4561 BIBN 4096
Potent and selective CGRP receptor antagonist
1181 CGRP 8-37 (human)
CGRP1 receptor antagonist
1169 CGRP 8-37 (rat)
CGRP1 receptor antagonist
4314 SB 268262
Selective non-peptide CGRP1 antagonist

Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid.

The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main function is inducing vasodilation, which causes hypotension. The CGRP receptor has also recently been implicated in the pathogenesis of migraine

External sources of pharmacological information for Calcitonin and Related Receptors :

Literature for Calcitonin and Related Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
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  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
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  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Calcitonin and Related Receptors Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CT Human CALCR NM_001742 P30988
Mouse Calcr NM_007588 Q60755
Rat Calcr NM_053816 P32214
CALCRL Human CALCRL NM_005795 Q16602
Mouse Calcrl NM_018782 Q9R1W5
Rat Calcrl NM_012717 Q63118
RAMP1 Human RAMP1 NM_005855 O60894
Mouse Ramp1 NM_016894 Q9WTJ5
Rat Ramp1 NM_031645 Q9JJ74
RAMP2 Human RAMP2 NM_005854 O60895
Mouse Ramp2 NM_019444 Q9WUP0
Rat Ramp2 NM_031646 Q9JHJ1
RAMP3 Human RAMP3 NM_005856 O60896
Mouse Ramp3 NM_019511 Q9WUP1
Rat Ramp3 NM_020100 Q9JJ73

CT and CALCRL form heterodimers with RAMP1-3, forming additional calcitonin related receptors; AMY1, AMY2, AMY3, CGRP, AM1 and AM2. (AMY1 = CT + RAMP1, AMY2 = CT + RAMP2, AMY3 = CT + RAMP3, CGRP = CALCRL + RAMP1, AM1 = CALCRL + RAMP2, AM2 = CALCRL + RAMP3)