BIBN 4096

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Cat.No. 4561 - BIBN 4096 | C38H47Br2N9O5 | CAS No. 204697-65-4
Description: Potent and selective CGRP receptor antagonist
Alternative Names: Olcegepant
Chemical Name: 1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective CGRP receptor antagonist (IC50 values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (Ki = 14.4 pM); exhibits no significant affinity for 75 other receptors.

Technical Data

M. Wt 869.65
Formula C38H47Br2N9O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 204697-65-4
PubChem ID 6918509
InChI Key ITIXDWVDFFXNEG-JHOUSYSJSA-N
Smiles O=C(N[C@H](CC4=CC(Br)=C(O)C(Br)=C4)C(N[C@@H](CCCCN)C(N5CCN(C6=CC=NC=C6)CC5)=O)=O)N(CC3)CCC3N2CC1=CC=CC=C1NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq.HCl 43.48 50
DMSO 43.48 50

Preparing Stock Solutions

The following data is based on the product molecular weight 869.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.75 mL 11.5 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.11 mL 0.57 mL 1.15 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Doods et al (2000) Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br.J.Pharmacol. 129 420 PMID: 10711339

Rudolf et al (2005) Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl J.Med.Chem. 48 5921 PMID: 16161996


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Keywords: BIBN4096 migraine potent selective CGRP receptors antagonists calcitonin gene-related peptides Olcegepant Olcegepant Calcitonin and Related Receptors

2 Citations for BIBN 4096

Citations are publications that use Tocris products. Selected citations for BIBN 4096 include:

Aubdool et al (2014) TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun 5 5732 PMID: 25501034

Engelstoft et al (2013) Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab 2 376 PMID: 24327954


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