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Description: Potent and selective CGRP antagonist
Alternative Names: Olcegepant
Chemical Name: 1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine
Purity: ≥95% (HPLC)
Biological Activity for BIBN 4096
BIBN 4096 is a potent and selective CGRP receptor antagonist (IC50 values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (Ki = 14.4 pM); exhibits no significant affinity for 75 other receptors.
Technical Data for BIBN 4096
| M. Wt | 869.65 |
| Formula | C38H47Br2N9O5 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 204697-65-4 |
| PubChem ID | 6918509 |
| InChI Key | ITIXDWVDFFXNEG-JHOUSYSJSA-N |
| Smiles | O=C(N[C@H](CC4=CC(Br)=C(O)C(Br)=C4)C(N[C@@H](CCCCN)C(N5CCN(C6=CC=NC=C6)CC5)=O)=O)N(CC3)CCC3N2CC1=CC=CC=C1NC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BIBN 4096
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.48 | 50 | |
| 2eq.HCl | 43.48 | 50 |
Preparing Stock Solutions for BIBN 4096
The following data is based on the product molecular weight 869.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.3 mL | 11.5 mL | 23 mL |
| 2.5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 25 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for BIBN 4096
References for BIBN 4096
References are publications that support the biological activity of the product.
Doods et al (2000) Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br.J.Pharmacol. 129 420 PMID: 10711339
Rudolf et al (2005) Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl J.Med.Chem. 48 5921 PMID: 16161996
If you know of a relevant reference for BIBN 4096, please let us know.
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Keywords: BIBN 4096, BIBN 4096 supplier, BIBN4096, migraine, potent, selective, CGRP, receptors, antagonists, calcitonin, gene-related, peptides, Olcegepant, Calcitonin, and, Related, Receptors, 4561, Tocris Bioscience
4 Citations for BIBN 4096
Citations are publications that use Tocris products. Selected citations for BIBN 4096 include:
Engelstoft et al (2013) Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab 2 376 PMID: 24327954
Aubdool et al (2014) TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun 5 5732 PMID: 25501034
Zhao and Levy (2018) The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization. Pain Rep 3 e632 PMID: 29430561
Pinho-Ribeiro et al (2018) Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell 173 1083 PMID: 29754819
Do you know of a great paper that uses BIBN 4096 from Tocris? Please let us know.
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