CGRP (rat)

Pricing Availability   Qty
Cat.No. 1161 - CGRP (rat) | Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge: 2-7) | CAS No. 83651-90-5
Description: Potent vasodilator
Alternative Names: Calcitonin Gene-Related Peptide (rat)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Endogenous neuropeptide; potent vasodilator which also exerts cardiovascular, pro-inflammatory and metabolic effects.

Technical Data

M. Wt 3807
Formula C162H262N50O52S2
Sequence SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

(Modifications: Disulfide bridge between 2 - 7, Phe-37 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 83651-90-5
PubChem ID 90479760
InChI Key SVAGNGUJZNLSEY-TYNJZYKVSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 0.80 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Brain et al (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313 54 PMID: 3917554

Morris et al (1984) Isolation and characterization of human calcitonin gene-related peptide. Nature 308 746 PMID: 6609312

Nakamura et al (1998) Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs. Brain Res. 807 203 PMID: 9757038

Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424 PMID: 8578616

Salim et al (1998) Calcitonin gene-related peptide potentiates nicotinic acetylcholine receptor-operated slow Ca2+ mobilization at mouse muscle endplates. Br.J.Pharmacol. 125 277 PMID: 9786499


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Keywords: CGRP (rat), CGRP (rat) supplier, Potent, vasodilator, CGRP, Receptors, calcitonin-gene, related, peptide, AMY1, AMY2, AMY3, agonists, Calcitonin, Gene-Related, Peptide, (rat), and, Related, 1161, Tocris Bioscience

4 Citations for CGRP (rat)

Citations are publications that use Tocris products. Selected citations for CGRP (rat) include:

Gutierrez and Boada (2019) Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+). Cancer Cell Int 18 216 PMID: 30598641

Zou et al (2016) Distinct calcitonin gene-related peptide expression pattern in primary afferents contribute to different neuropathic symptoms following chronic constriction or crush injuries to the rat sciatic nerve. Mol Pain 12 1 PMID: 28256957

Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. Mol Pain 315 1380 PMID: 16160082

Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Elife 4 12 PMID: 18416824


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Literature in this Area

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