CGRP (rat)

Pricing Availability Delivery Time Qty
Cat.No. 1161 - CGRP (rat) | Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge: 2-7) | CAS No. 83651-90-5
Description: Potent vasodilator
Alternative Names: Calcitonin Gene-Related Peptide (rat)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Endogenous neuropeptide; potent vasodilator which also exerts cardiovascular, pro-inflammatory and metabolic effects.

Technical Data

M. Wt 3807
Formula C162H262N50O52S2
Sequence SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

(Modifications: Disulfide bridge between 2 - 7, Phe-37 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 83651-90-5
PubChem ID 90479760
InChI Key SVAGNGUJZNLSEY-TYNJZYKVSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.80 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3807. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.26 mL 1.31 mL 2.63 mL
5 mM 0.05 mL 0.26 mL 0.53 mL
10 mM 0.03 mL 0.13 mL 0.26 mL
50 mM 0.01 mL 0.03 mL 0.05 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Brain et al (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313 54 PMID: 3917554

Morris et al (1984) Isolation and characterization of human calcitonin gene-related peptide. Nature 308 746 PMID: 6609312

Nakamura et al (1998) Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs. Brain Res. 807 203 PMID: 9757038

Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424 PMID: 8578616

Salim et al (1998) Calcitonin gene-related peptide potentiates nicotinic acetylcholine receptor-operated slow Ca2+ mobilization at mouse muscle endplates. Br.J.Pharmacol. 125 277 PMID: 9786499


If you know of a relevant reference for CGRP (rat), please let us know.

View Related Products by Target

View Related Products by Product Action

View all Calcitonin and Related Receptor Agonists

Keywords: CGRP (rat), supplier, Potent, vasodilator, CGRP, Receptors, calcitonin-gene, related, peptide, AMY1, AMY2, AMY3, agonists, Calcitonin, Gene-Related, Peptide, (rat), Calcitonin, and, Related, Receptors, Calcitonin, and, Related, Receptors, Tocris Bioscience

2 Citations for CGRP (rat)

Citations are publications that use Tocris products. Selected citations for CGRP (rat) include:

Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. Mol Pain 315 1380 PMID: 16160082

Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Elife 4 12 PMID: 18416824


Do you know of a great paper that uses CGRP (rat) from Tocris? If so please let us know.

Reviews for CGRP (rat)

There are currently no reviews for this product. Be the first to review CGRP (rat) and earn rewards!

Have you used CGRP (rat)?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.