CGRP 8-37 (rat)

Pricing Availability Delivery Time Qty
Cat.No. 1169 - CGRP 8-37 (rat) | Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 | CAS No. 129121-73-9
Description: CGRP1 receptor antagonist
Alternative Names: Calcitonin Gene-Related Peptide 8-37 (rat)
Datasheet
Citations (1)
Literature

Biological Activity

Peptide antagonist for CGRP1 receptors.

Technical Data

M. Wt 3127.5
Formula C138H224N42O41
Sequence VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

(Modifications: Phe-30 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 129121-73-9
PubChem ID 90479762
InChI Key HZKKKBMPFPSSKZ-QZMRZBIOSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3127.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.32 mL 1.6 mL 3.2 mL
5 mM 0.06 mL 0.32 mL 0.64 mL
10 mM 0.03 mL 0.16 mL 0.32 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424 PMID: 8578616

Poyner et al (1998) Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br.J.Pharmacol. 124 1659 PMID: 9756381

Wisskirchen et al (1998) Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br.J.Pharmacol. 123 1673 PMID: 9605575


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1 Citation for CGRP 8-37 (rat)

Citations are publications that use Tocris products. Selected citations for CGRP 8-37 (rat) include:

Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Cell Mol Med 315 1380 PMID: 16160082


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