CGRP 8-37 (rat)

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Cat.No. 1169 - CGRP 8-37 (rat) | Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 | CAS No. 129121-73-9
Description: CGRP1 receptor antagonist
Alternative Names: Calcitonin Gene-Related Peptide 8-37 (rat)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Peptide antagonist for CGRP1 receptors.

Technical Data

M. Wt 3127.5
Formula C138H224N42O41
Sequence VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

(Modifications: Phe-30 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 129121-73-9
PubChem ID 90479762
InChI Key HZKKKBMPFPSSKZ-QZMRZBIOSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424 PMID: 8578616

Poyner et al (1998) Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br.J.Pharmacol. 124 1659 PMID: 9756381

Wisskirchen et al (1998) Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br.J.Pharmacol. 123 1673 PMID: 9605575


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3 Citations for CGRP 8-37 (rat)

Citations are publications that use Tocris products. Selected citations for CGRP 8-37 (rat) include:

Khodorova et al (2009) Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1. J Pain 10 740 PMID: 19559390

Tozzi et al (2012) Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. Proc Natl Acad Sci U S A 109 18985 PMID: 23112192

Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Cell Mol Med 315 1380 PMID: 16160082


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Literature in this Area

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