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Orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
(Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Jhamandas and MacTavish (2004) Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons. J.Neurosci. 24 5579 PMID: 15201330
Gedulin et al (2006) Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul.Pept. 137 121 PMID: 16914214
Reidelberger et al (2004) Amylin receptor blockade stimulates food intake in rats. Am.J.Physiol.Inter.Comp.Physiol. 287 R568
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Keywords: AC 187, AC 187 supplier, Potent, selective, amylin, receptors, antagonists, AC187, Calcitonin, and, Related, Receptors, 3419, Tocris Bioscience
2 Citations for AC 187
Citations are publications that use Tocris products. Selected citations for AC 187 include:
Baisley et al (2014) Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression. J Neurosci 34 4318 PMID: 24647952
Liberini et al (2016) The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats. Mol Metab 5 834 PMID: 27688997
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