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Submit ReviewBiological Activity for Pramlintide
Pramlintide is a synthetic version of amylin (Cat. No. 3418). Exhibits high affinity for amylin, CGRP and calcitonin receptors (Ki values are 0.023, 3.8 and 5.1 nM respectively). Reduces postprandial hyperglycemia; also inhibits gastric emptying.
Technical Data for Pramlintide
| M. Wt | 3949.42 |
| Formula | C171H267N51O53S2 |
| Sequence |
KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY (Modifications: Tyr-37 = C-terminal amide, Disulfide bridge: 2-7) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 151126-32-8 |
| PubChem ID | 70691388 |
| InChI Key | TZIRZGBAFTZREM-MKAGXXMWSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pramlintide
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Pramlintide
References for Pramlintide
References are publications that support the biological activity of the product.
Young et al (1996) Preclinical pharmacology of pramli. in the rat: comparisons with human and rat amylin. Drug Dev.Res. 37 231
Hoogwerf et al (2008) Pramlintide, the synthetic analogue of amylin: phsyiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk. Vasc.Health Risk Manag. 4 355 PMID: 18561511
If you know of a relevant reference for Pramlintide, please let us know.
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Keywords: Pramlintide, Pramlintide supplier, Pramlintide, antidiabetic, amylin, synthetic, calcitonin, CGRP, receptors, Calcitonin, and, Related, Receptors, 5031, Tocris Bioscience
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