α-CGRP (human)

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Description: CGRP agonist
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (3)

Biological Activity for α-CGRP (human)

α-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist. It is a long-lasting vasodilator. α-CGRP (human) also reduces the secretion of both mouse Ins1 and Ins2 proteins and remodels amylin fibrillization in mouse pancreatic β-cells.

Technical Data for α-CGRP (human)

M. Wt 3789.33
Formula C163H267N51O49S2
Sequence ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF

(Modifications: Phe-37 = C-terminal amide, Disulfide bridge: 2-7)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 90954-53-3
PubChem ID 44563440
InChI Key JMJJWZFCOWFIBU-XJVRLEFXSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for α-CGRP (human)

Solubility Soluble to 0.50 mg/ml in water

Product Datasheets for α-CGRP (human)

Certificate of Analysis / Product Datasheet
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References for α-CGRP (human)

References are publications that support the biological activity of the product.

Poyner et al (2002) International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol.Revs. 54 233

Gray et al (2021) α-CGRP disrupts amylin fibrillization and regulates insulin secretion: implications on diabetes and migraine. Chem.Sci. 12 5853 PMID: 34168810

Kee et al (2018) The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects. Front Physiol. 9 1249 PMID: 30283343


If you know of a relevant reference for α-CGRP (human), please let us know.

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Keywords: alpha-CGRP (human), alpha-CGRP (human) supplier, CGRP, receptor, agonists, Receptors, calcitonin, amylin, AMY, alpha-CGRP, (human), α-CGRP, a-CGRP, pancreatic, beta-cells, Calcitonin, and, Related, 3012, Tocris Bioscience

Citations for α-CGRP (human)

Citations are publications that use Tocris products.

Currently there are no citations for α-CGRP (human). Do you know of a great paper that uses α-CGRP (human) from Tocris? Please let us know.

Reviews for α-CGRP (human)

Average Rating: 5 (Based on 1 Review.)

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Potent CGRP agonist.
By Anonymous on 09/20/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Hek 293 Cells

in in vitro study (Hek 293 cells), stimulate CGRP Receptor (CLR) on the plasma membrane causing internalization.

Easy to dissolve in DMSO, stock solution concentration 10mM.


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