You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for DMH2
DMH2 is a type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
Technical Data for DMH2
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DMH2
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||9.03||20 with gentle warming|
Preparing Stock Solutions for DMH2
The following data is based on the product molecular weight 451.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.43 mL||22.15 mL||44.29 mL|
|2.5 mM||0.89 mL||4.43 mL||8.86 mL|
|5 mM||0.44 mL||2.21 mL||4.43 mL|
|25 mM||0.09 mL||0.44 mL||0.89 mL|
References for DMH2
References are publications that support the biological activity of the product.
Tsugawa et al (2014) Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549 PMID: 25271257
If you know of a relevant reference for DMH2, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: DMH2, DMH2 supplier, Type-1, BMP, bone, morphogenetic, protein, receptors, inhibitors, inhibits, ALK6, ALK2, ALK3, and, Other, Activin, Receptors, 5580, Tocris Bioscience
1 Citation for DMH2
Citations are publications that use Tocris products. Selected citations for DMH2 include:
Stuart et al (2019) Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell 25 388 PMID: 31422912
Do you know of a great paper that uses DMH2 from Tocris? Please let us know.
Reviews for DMH2
There are currently no reviews for this product. Be the first to review DMH2 and earn rewards!
Have you used DMH2?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.