DMH2

Pricing Availability Delivery Time Qty
Cat.No. 5580 - DMH2 | C27H25N5O2 | CAS No. 1206711-14-9
Description: Type I BMP receptor inhibitor
Chemical Name: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.

Technical Data

M. Wt 451.52
Formula C27H25N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1206711-14-9
PubChem ID 50997748
InChI Key DXLXRNZCYAYUED-UHFFFAOYSA-N
Smiles C(C=N2)(C3=CC=C(OCCN4CCOCC4)C=C3)=CN1C2=C(C5=CC=NC6=C5C=CC=C6)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq.HCl 22.58 50
DMSO 9.03 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 451.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tsugawa et al (2014) Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549 PMID: 25271257


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View Related Products by Product Action

View all BMP and Other Activin Receptor Inhibitors

Keywords: DMH2, supplier, Type-1, BMP, bone, morphogenetic, protein, receptors, inhibitors, inhibits, ALK6, ALK2, ALK3, BMP, and, Other, Activin, Receptors, BMP, and, Other, Activin, Receptors, Tocris Bioscience

Citations for DMH2

Citations are publications that use Tocris products.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for DMH2

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

Protocols

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