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Type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||9.03||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 451.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.43 mL||22.15 mL||44.29 mL|
|2.5 mM||0.89 mL||4.43 mL||8.86 mL|
|5 mM||0.44 mL||2.21 mL||4.43 mL|
|25 mM||0.09 mL||0.44 mL||0.89 mL|
References are publications that support the biological activity of the product.
Tsugawa et al (2014) Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549 PMID: 25271257
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Keywords: DMH2, DMH2 supplier, Type-1, BMP, bone, morphogenetic, protein, receptors, inhibitors, inhibits, ALK6, ALK2, ALK3, and, Other, Activin, Receptors, 5580, Tocris Bioscience
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Literature in this Area
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