SB 505124

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Cat.No. 3263 - SB 505124 | C20H21N3O2 | CAS No. 694433-59-5
Description: Selective inhibitor of TGF-βRI, ALK4 and ALK7
Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (5)
Pathways (1)

Biological Activity

Selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members.

Technical Data

M. Wt 335.4
Formula C20H21N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 694433-59-5
PubChem ID 9858940
InChI Key WGZOTBUYUFBEPZ-UHFFFAOYSA-N
Smiles CC(C)(C)C1=NC(C2=CC(OCO4)=C4C=C2)=C(C3=NC(C)=CC=C3)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.54 100
1eq. HCl 33.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Byfield et al (2004) SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 65 744 PMID: 14978253

Hu et al (2005) Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells. Am.J.Physiol.Renal Physiol. 289 F816 PMID: 16159901

Noma et al (2008) The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 134 1981 PMID: 18439605


If you know of a relevant reference for SB 505124, please let us know.

View Related Products by Product Action

View all TGF-β Receptor Inhibitors

Keywords: SB 505124, SB 505124 supplier, SB505124, tgfβ, tgfbeta, tgfb, tgfbrI, tgfbetarI, tgfβrI, receptors, transforming, growth, factors, alk5, alk4, alk7, inhibitors, inhibits, TGF-beta, Receptors, BMP, and, Other, Activin, 3263, Tocris Bioscience

5 Citations for SB 505124

Citations are publications that use Tocris products. Selected citations for SB 505124 include:

Ramel and Hill (2013) The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol 378 170 PMID: 23499658

Boxtel et al (2015) A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Dev Cell 35 175 PMID: 26506307

Yang et al (2017) Establishment of mouse expanded potential stem cells. Nature 550 393 PMID: 29019987

Asghar et al (2017) Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis. Oncol Lett 14 5497 PMID: 29113177

Zhu et al (2016) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35 5388 PMID: 27109105


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for SB 505124

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.