Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 352.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.84 mL||14.19 mL||28.38 mL|
|5 mM||0.57 mL||2.84 mL||5.68 mL|
|10 mM||0.28 mL||1.42 mL||2.84 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References are publications that support the products' biological activity.
Engers et al (2013) Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Bioorg Med Chem Lett. 23 3248 PMID: 23639540
If you know of a relevant reference for ML 347, please let us know.
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Keywords: ML 347, supplier, ML347, Potent, selective, ALK1, ALK2, BMP, activin, receptor, like, kinase, Bone, morphogenetic, proteins, inhibitors, inhibits, LDN, 193719, 1LWY, VU0469381, BMP, and, Other, Activin, Receptors, BMP, and, Other, Activin, Receptors, Tocris Bioscience
1 Citation for ML 347
Citations are publications that use Tocris products. Selected citations for ML 347 include:
Varadaraj et al (2015) Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia 17 826 PMID: 26678910
Do you know of a great paper that uses ML 347 from Tocris? If so please let us know.
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Literature in this Area
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