ML 347

Pricing Availability Delivery Time Qty
Cat.No. 4945 - ML 347 | C22H16N4O | CAS No. 1062368-49-3
Description: Potent and selective ALK1 and ALK2 inhibitor
Alternative Names: LDN 193719, 1lWY, VU0469381
Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).

Compound Libraries

ML 347 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 352.39
Formula C22H16N4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1062368-49-3
PubChem ID 44577753
InChI Key FVRYPYDPKSZGNS-UHFFFAOYSA-N
Smiles COC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=CC5=C4C=CC=N5)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.05 20

Preparing Stock Solutions

The following data is based on the product molecular weight 352.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Engers et al (2013) ynthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Bioorg Med Chem Lett. 23 3248 PMID: 23639540


If you know of a relevant reference for ML 347, please let us know.

View Related Products by Product Action

View all BMP and Other Activin Receptor Inhibitors

Keywords: ML347 Potent selective ALK1 ALK2 BMP activin receptor like kinase Bone morphogenetic proteins inhibitors inhibits LDN 193719 1LWY VU0469381 BMP and Other Activin Receptors

1 Citation for ML 347

Citations are publications that use Tocris products. Selected citations for ML 347 include:

Varadaraj et al (2015) Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia 17 826 PMID: 26678910


Do you know of a great paper that uses ML 347 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for ML 347

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

Protocols

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