K 02288

Pricing Availability   Qty
Cat.No. 4986 - K 02288 | C20H20N2O4 | CAS No. 1431985-92-0
Description: Type 1 BMP receptor inhibitor
Alternative Names: K 02288a
Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.

Compound Libraries

K 02288 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 352.38
Formula C20H20N2O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1431985-92-0
PubChem ID 46173038
InChI Key CJLMANFTWLNAKC-UHFFFAOYSA-N
Smiles NC1=NC=C(C3=CC=CC(O)=C3)C=C1C2=CC(OC)=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.24 100
ethanol 3.52 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 352.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Sanvitale et al (2013) A new class of small molecule inhibitor of BMP signaling. PLoS ONE 8 62721 PMID: 23646137

Mohedas et al (2013) Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 8 1291 PMID: 23547776


If you know of a relevant reference for K 02288, please let us know.

View Related Products by Product Action

View all BMP and Other Activin Receptor Inhibitors

Keywords: K 02288, K 02288 supplier, potent, selective, bone, morphogenic, protein, BMP, ALK2, inhibitors, inhibits, K02288, K02288a, K, 02288a, and, Other, Activin, Receptors, 4986, Tocris Bioscience

1 Citation for K 02288

Citations are publications that use Tocris products. Selected citations for K 02288 include:

Bui et al (2015) SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy. Cell Cycle 14 1218 PMID: 25706341


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for K 02288

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.