Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||3.52||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 352.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.84 mL||14.19 mL||28.38 mL|
|5 mM||0.57 mL||2.84 mL||5.68 mL|
|10 mM||0.28 mL||1.42 mL||2.84 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References are publications that support the biological activity of the product.
Sanvitale et al (2013) A new class of small molecule inhibitor of BMP signaling. PLoS ONE 8 62721 PMID: 23646137
Mohedas et al (2013) Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 8 1291 PMID: 23547776
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Keywords: K 02288, K 02288 supplier, potent, selective, bone, morphogenic, protein, BMP, ALK2, inhibitors, inhibits, K02288, K02288a, K, 02288a, and, Other, Activin, Receptors, 4986, Tocris Bioscience
1 Citation for K 02288
Citations are publications that use Tocris products. Selected citations for K 02288 include:
Bui et al (2015) SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy. Cell Cycle 14 1218 PMID: 25706341
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