K 02288

Pricing Availability Delivery Time Qty
Cat.No. 4986 - K 02288 | C20H20N2O4 | CAS No. 1431985-92-0
Description: Type 1 BMP receptor inhibitor
Alternative Names: K 02288a
Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.

Compound Libraries

K 02288 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 352.38
Formula C20H20N2O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1431985-92-0
PubChem ID 46173038
InChI Key CJLMANFTWLNAKC-UHFFFAOYSA-N
Smiles NC1=NC=C(C3=CC=CC(O)=C3)C=C1C2=CC(OC)=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.24 100
ethanol 3.52 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 352.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sanvitale et al (2013) A new class of small molecule inhibitor of BMP signaling. PLoS ONE 8 62721 PMID: 23646137

Mohedas et al (2013) Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 8 1291 PMID: 23547776


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View Related Products by Product Action

View all BMP and Other Activin Receptor Inhibitors

Keywords: potent selective bone morphogenic protein BMP ALK2 inhibitors inhibits K02288 K02288a K 02288a K 02288a BMP and Other Activin Receptors

Citations for K 02288

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for K 02288

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

Protocols

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