M4K2163 dihydrochloride

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Description: Potent and selective ALK2 inhibitor
Chemical Name: 1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)
Pathways (1)

Biological Activity for M4K2163 dihydrochloride

M4K2163 is a potent and selective activin receptor-like kinase 2 (ALK2) inhibitor (IC50 values are 19 nM in vivo and 98 nM in vitro). Orally bioavailable and brain penetrant.

Technical Data for M4K2163 dihydrochloride

M. Wt 480.41
Formula C24H26FN3O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key HMNLQIQCOZETBK-UHFFFAOYSA-N
Smiles FC1=C(OC)C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for M4K2163 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 48.04 100
DMSO 48.04 100

Preparing Stock Solutions for M4K2163 dihydrochloride

The following data is based on the product molecular weight 480.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.41 mL 20.82 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for M4K2163 dihydrochloride

References for M4K2163 dihydrochloride

References are publications that support the biological activity of the product.

Smil et al (2020) Leveraging an open science drug discovery model to develop CNS-penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma. J.Med.Chem. 63 10061 PMID: 32787083

Rooney and Jones (2021) Recent advances in ALK2 inhibitors. ACS Omega 6 20729 PMID: 34423181


If you know of a relevant reference for M4K2163 dihydrochloride, please let us know.

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Citations for M4K2163 dihydrochloride

Citations are publications that use Tocris products.

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Reviews for M4K2163 dihydrochloride

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Literature in this Area

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Pathways for M4K2163 dihydrochloride

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.