Aryl Hydrocarbon Receptors

Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
5304 FICZ
High affinity aryl hydrocarbon receptor (AhR) agonist
1803 ITE
Endogenous agonist for the transcription factor aryl hydrocarbon receptor
3873 MeBIO
AhR agonist. Inactive analog of BIO (Cat. No. 3194)
1267 Pifithrin-α hydrobromide
Aryl hydrocarbon receptor agonist. Also p53 inhibitor

Antagonists

Cat No Product Name / Activity
3858 CH 223191
Potent aryl hydrocarbon receptor (AhR) antagonist
3859 6,2',4'-Trimethoxyflavone
Aryl hydrocarbon receptor antagonist

Modulators

Cat No Product Name / Activity
4628 DiMNF
Selective aryl hydrocarbon receptor modulator (SAhRM)

Ligands

Cat No Product Name / Activity
4393 L-Kynurenine
Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand

Other

Cat No Product Name / Activity
4995 Phortress
Prodrug of the antitumor agent 5F 203

Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize with AHR nuclear translocator (ARNT) and alter transcription of target genes.

AHR is an evolutionary conserved receptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizing enzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized to chromosome 7p15.

Literature for Aryl Hydrocarbon Receptors

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Aryl Hydrocarbon Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human AHR NM_001621 P35869
Mouse Ahr NM_013464 Q8R4S5
Rat Ahr NM_013149 P41738