Aryl Hydrocarbon Receptors
Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.
Aryl Hydrocarbon Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 6321 | 10-Cl-BBQ |
| Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable | |
| 5304 | FICZ |
| High affinity aryl hydrocarbon receptor (AhR) agonist | |
| 1803 | ITE |
| Endogenous agonist for the transcription factor aryl hydrocarbon receptor | |
| 3873 | MeBIO |
| AhR agonist. Inactive analog of BIO (Cat. No. 3194) | |
| 1267 | Pifithrin-α hydrobromide |
| Aryl hydrocarbon receptor agonist. Also p53 inhibitor | |
Aryl Hydrocarbon Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 3858 | CH 223191 |
| Potent aryl hydrocarbon receptor (AhR) antagonist | |
| 7086 | StemRegenin 1 |
| Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment | |
Ligands |
|
| Cat. No. | Product Name / Activity |
| 4393 | L-Kynurenine |
| Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand | |
Other |
|
| Cat. No. | Product Name / Activity |
| 4995 | Phortress |
| Prodrug of the antitumor agent 5F 203 | |
Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize with AHR nuclear translocator (ARNT) and alter transcription of target genes.
AHR is an evolutionary conserved receptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizing enzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized to chromosome 7p15.