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Aryl Hydrocarbon Receptors

Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.

Products
Background
Literature (1)
Gene Data

Aryl Hydrocarbon Receptor Agonists
Cat. No. Product Name / Activity
6321 10-Cl-BBQ
Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
5304 FICZ
High affinity aryl hydrocarbon receptor (AhR) agonist
1803 ITE
Endogenous agonist for the transcription factor aryl hydrocarbon receptor
3873 MeBIO
AhR agonist. Inactive analog of BIO (Cat. No. 3194)
1267 Pifithrin-α hydrobromide
Aryl hydrocarbon receptor agonist. Also p53 inhibitor

Aryl Hydrocarbon Receptor Antagonists
Cat. No. Product Name / Activity
3858 CH 223191
Potent aryl hydrocarbon receptor (AhR) antagonist
7086 StemRegenin 1
Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

Ligands
Cat. No. Product Name / Activity
4393 L-Kynurenine
Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand

Other
Cat. No. Product Name / Activity
4995 Phortress
Prodrug of the antitumor agent 5F 203

Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize with AHR nuclear translocator (ARNT) and alter transcription of target genes.

AHR is an evolutionary conserved receptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizing enzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized to chromosome 7p15.

External sources of pharmacological information for Aryl Hydrocarbon Receptors :

    Literature for Aryl Hydrocarbon Receptors

    Tocris offers the following scientific literature for Aryl Hydrocarbon Receptors to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Nuclear Receptors Product Listing

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

    • Androgen Receptors
    • Estrogen Receptors
    • Retinoic Acid Receptors
    • Retinoid X Receptors
    • Vitamin D Receptors

    Aryl Hydrocarbon Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human AHR NM_001621 P35869
    Mouse Ahr NM_013464 Q8R4S5
    Rat Ahr NM_013149 P41738