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10-Cl-BBQ is a potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC50 = 2.6 nM). Directly binds CD4+ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||0.3||1 with gentle warming|
The following data is based on the product molecular weight 304.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.01 mM||328.16 mL||1640.8 mL||3281.59 mL|
|0.05 mM||65.63 mL||328.16 mL||656.32 mL|
|0.1 mM||32.82 mL||164.08 mL||328.16 mL|
|0.5 mM||6.56 mL||32.82 mL||65.63 mL|
References are publications that support the biological activity of the product.
Punj et al (2014) Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One 9 e88726 PMID: 24586378
Ehrlich et al (2016) Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T Cells in nonobese diabetic mice. J.Immunol. 196 264 PMID: 26573835
If you know of a relevant reference for 10-Cl-BBQ, please let us know.
Keywords: 10-Cl-BBQ, 10-Cl-BBQ supplier, Potent, aryl, hydrocarbon, receptor, AhR, agonists, antagonism, Tregs, insulitis, orally, bioavailable, Aryl, Hydrocarbon, Receptors, 6321, Tocris Bioscience
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