High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||14.07 mL||70.35 mL||140.69 mL|
|1.25 mM||2.81 mL||14.07 mL||28.14 mL|
|2.5 mM||1.41 mL||7.03 mL||14.07 mL|
|12.5 mM||0.28 mL||1.41 mL||2.81 mL|
References are publications that support the biological activity of the product.
Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841 PMID: 8807817
Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690 PMID: 19054769
Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387 PMID: 25119038
If you know of a relevant reference for FICZ, please let us know.
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Keywords: FICZ, FICZ supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, Aryl, Hydrocarbon, Receptors, 5304, Tocris Bioscience
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