Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewFICZ
Description: High affinity aryl hydrocarbon receptor (AhR) agonist
Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Purity: ≥95% (HPLC)
Biological Activity
High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
Technical Data
| M. Wt | 284.31 |
| Formula | C19H12N2O |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 172922-91-7 |
| PubChem ID | 1863 |
| InChI Key | ZUDXFBWDXVNRKF-UHFFFAOYSA-N |
| Smiles | [H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.11 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 14.07 mL | 70.35 mL | 140.69 mL |
| 1.25 mM | 2.81 mL | 14.07 mL | 28.14 mL |
| 2.5 mM | 1.41 mL | 7.03 mL | 14.07 mL |
| 12.5 mM | 0.28 mL | 1.41 mL | 2.81 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841 PMID: 8807817
Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690 PMID: 19054769
Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387 PMID: 25119038
If you know of a relevant reference for FICZ, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: FICZ, FICZ supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, Aryl, Hydrocarbon, Receptors, 5304, Tocris Bioscience
1 Citation for FICZ
Citations are publications that use Tocris products. Selected citations for FICZ include:
Tagliabue et al (2019) Modeling the binding of diverse ligands within the Ah receptor ligand binding domain. Sci Rep 9 10693 PMID: 31337850
Do you know of a great paper that uses FICZ from Tocris? Please let us know.
Reviews for FICZ
There are currently no reviews for this product. Be the first to review FICZ and earn rewards!
Have you used FICZ?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nuclear Receptors Product Listing
A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:
- Androgen Receptors
- Estrogen Receptors
- Retinoic Acid Receptors
- Retinoid X Receptors
- Vitamin D Receptors