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Description: High affinity aryl hydrocarbon receptor (AhR) agonist
Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Purity: ≥95% (HPLC)
Biological Activity
High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
Technical Data
| M. Wt | 284.31 |
| Formula | C19H12N2O |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 172922-91-7 |
| PubChem ID | 1863 |
| InChI Key | ZUDXFBWDXVNRKF-UHFFFAOYSA-N |
| Smiles | [H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.11 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 14.07 mL | 70.35 mL | 140.69 mL |
| 1.25 mM | 2.81 mL | 14.07 mL | 28.14 mL |
| 2.5 mM | 1.41 mL | 7.03 mL | 14.07 mL |
| 12.5 mM | 0.28 mL | 1.41 mL | 2.81 mL |
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References
References are publications that support the biological activity of the product.
Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841 PMID: 8807817
Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690 PMID: 19054769
Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387 PMID: 25119038
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Keywords: FICZ, FICZ supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, Aryl, Hydrocarbon, Receptors, 5304, Tocris Bioscience
1 Citation for FICZ
Citations are publications that use Tocris products. Selected citations for FICZ include:
Tagliabue et al (2019) Modeling the binding of diverse ligands within the Ah receptor ligand binding domain. Sci Rep 9 10693 PMID: 31337850
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