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Description: High affinity aryl hydrocarbon receptor (AhR) agonist
Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Purity: ≥95% (HPLC)
Citations (6)

Biological Activity for FICZ

FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Technical Data for FICZ

M. Wt 284.31
Formula C19H12N2O
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 172922-91-7
PubChem ID 1863
Smiles [H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FICZ

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.11 25

Preparing Stock Solutions for FICZ

The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 14.07 mL 70.35 mL 140.69 mL
1.25 mM 2.81 mL 14.07 mL 28.14 mL
2.5 mM 1.41 mL 7.03 mL 14.07 mL
12.5 mM 0.28 mL 1.41 mL 2.81 mL

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Product Datasheets for FICZ

Certificate of Analysis / Product Datasheet
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References for FICZ

References are publications that support the biological activity of the product.

Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841 PMID: 8807817

Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690 PMID: 19054769

Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387 PMID: 25119038

If you know of a relevant reference for FICZ, please let us know.

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Keywords: FICZ, FICZ supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, hematopoietic, haematopoietic, stem, cells, HSC, Aryl, Hydrocarbon, Receptors, Hematopoietic, Stem, Cells, 5304, Tocris Bioscience

6 Citations for FICZ

Citations are publications that use Tocris products. Selected citations for FICZ include:

Igor et al (2020) Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat Immunol 21 1421-1429 PMID: 32929273

Ewa et al (2020) Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies. Int J Mol Sci 21 PMID: 33114713

Tagliabue et al (2019) Modeling the binding of diverse ligands within the Ah receptor ligand binding domain. Sci Rep 9 10693 PMID: 31337850

Brian T et al (2021) Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol 12 715059 PMID: 34408754

Do you know of a great paper that uses FICZ from Tocris? Please let us know.

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