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Biological Activity for FICZ
FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
Technical Data for FICZ
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FICZ
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FICZ
The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||14.07 mL||70.35 mL||140.69 mL|
|1.25 mM||2.81 mL||14.07 mL||28.14 mL|
|2.5 mM||1.41 mL||7.03 mL||14.07 mL|
|12.5 mM||0.28 mL||1.41 mL||2.81 mL|
References for FICZ
References are publications that support the biological activity of the product.
Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841 PMID: 8807817
Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690 PMID: 19054769
Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387 PMID: 25119038
If you know of a relevant reference for FICZ, please let us know.
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Keywords: FICZ, FICZ supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, hematopoietic, haematopoietic, stem, cells, HSC, Aryl, Hydrocarbon, Receptors, Hematopoietic, Stem, Cells, 5304, Tocris Bioscience
6 Citations for FICZ
Citations are publications that use Tocris products. Selected citations for FICZ include:
Tagliabue et al (2019) Modeling the binding of diverse ligands within the Ah receptor ligand binding domain. Sci Rep 9 10693 PMID: 31337850
Brian T et al (2021) Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol 12 715059 PMID: 34408754
Carsten et al (2021) Macrophages Control the Bioavailability of Vitamin D and Vitamin D-Regulated T Cell Responses. Front Immunol 12 722806 PMID: 34621269
Ada et al (2022) Identification of environmental factors that promote intestinal inflammation. Nature 611 801-809 PMID: 36266581
Igor et al (2020) Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat Immunol 21 1421-1429 PMID: 32929273
Ewa et al (2020) Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies. Int J Mol Sci 21 PMID: 33114713
Do you know of a great paper that uses FICZ from Tocris? Please let us know.
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