FICZ

Pricing Availability   Qty
Cat.No. 5304 - FICZ | C19H12N2O | CAS No. 172922-91-7
Description: High affinity aryl hydrocarbon receptor (AhR) agonist
Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Technical Data

M. Wt 284.31
Formula C19H12N2O
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 172922-91-7
PubChem ID 1863
InChI Key ZUDXFBWDXVNRKF-UHFFFAOYSA-N
Smiles [H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.11 25

Preparing Stock Solutions

The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 14.07 mL 70.35 mL 140.69 mL
1.25 mM 2.81 mL 14.07 mL 28.14 mL
2.5 mM 1.41 mL 7.03 mL 14.07 mL
12.5 mM 0.28 mL 1.41 mL 2.81 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841 PMID: 8807817

Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690 PMID: 19054769

Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387 PMID: 25119038


If you know of a relevant reference for FICZ, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Aryl Hydrocarbon Receptor Agonists

Keywords: FICZ, FICZ supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, Aryl, Hydrocarbon, Receptors, 5304, Tocris Bioscience

Citations for FICZ

Citations are publications that use Tocris products.

Currently there are no citations for FICZ. Do you know of a great paper that uses FICZ from Tocris? Please let us know.

Reviews for FICZ

There are currently no reviews for this product. Be the first to review FICZ and earn rewards!

Have you used FICZ?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors