Pricing Availability   Qty
Cat.No. 4995 - Phortress | C20H23FN4OS.2HCl | CAS No. 328087-38-3
Description: Prodrug of the antitumor agent 5F 203
Chemical Name: (2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells.

Technical Data

M. Wt 459.41
Formula C20H23FN4OS.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 328087-38-3
PubChem ID 9804228
Smiles FC1=CC=C2C(N=C(C3=CC=C(NC([C@H](CCCCN)N)=O)C(C)=C3)S2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO


References are publications that support the biological activity of the product.

Leong et al (2003) Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Br.J.Cancer 88 470 PMID: 12569393

Leong et al (2004) In vitro, in vivo and in silico analyses of the antitumor activity of 2(-4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Mol.Cancer Ther. 3 1565 PMID: 15634650

Trapani et al (2003) DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated by aryl hydrocarbon receptor deficient MCF-7 cells. Br.J.Cancer 88 599 PMID: 12592376

Bradshaw and Westwell (2004) The development of the antitumour benzothiazole prodrug, phortress, as a clinical candidate. Curr.Med.Chem. 11 1241 PMID: 15078163

If you know of a relevant reference for Phortress, please let us know.

View Related Products by Target

Keywords: Phortress, Phortress supplier, antitumor, antitumour, cytotoxic, prodrug, aryl, hydrocarbon, receptors, AhRs, Aryl, Hydrocarbon, Receptors, 4995, Tocris Bioscience

Citations for Phortress

Citations are publications that use Tocris products.

Currently there are no citations for Phortress. Do you know of a great paper that uses Phortress from Tocris? Please let us know.

Reviews for Phortress

There are currently no reviews for this product. Be the first to review Phortress and earn rewards!

Have you used Phortress?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors