CVT 10216

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Cat.No. 5164 - CVT 10216 | C24H19NO7S | CAS No. 1005334-57-5
Description: Potent and selective ALDH2 inhibitor
Chemical Name: 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid
Purity: ≥98% (HPLC)

Biological Activity

Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.

Compound Libraries

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Technical Data

M. Wt 465.48
Formula C24H19NO7S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1005334-57-5
PubChem ID 23661666
Smiles O=C2C1=CC=C(OCC4=CC(C(O)=O)=CC=C4)C=C1OC=C2C3=CC=C(NS(=O)(C)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 23.27 50
DMSO 46.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 465.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Overstreet et al (2009) A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol.Biochem.Behav. 94 255 PMID: 19747934

Yao et al (2010) Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis. Nat.Med. 16 1024 PMID: 20729865

If you know of a relevant reference for CVT 10216, please let us know.

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Keywords: CVT10216 potent selective reversible inhibitors inhibits aldehyde dehydrogenase 2 ALDH2 anxiolytics anti-anxiety Aldehyde Dehydrogenase

Citations for CVT 10216

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Pathways for CVT 10216


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