Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.74 mL||21.48 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
|10 mM||0.21 mL||1.07 mL||2.15 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the products' biological activity.
Overstreet et al (2009) A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol.Biochem.Behav. 94 255 PMID: 19747934
Yao et al (2010) Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis. Nat.Med. 16 1024 PMID: 20729865
If you know of a relevant reference for CVT 10216, please let us know.
View Related Products by Product Action
Keywords: CVT 10216, supplier, CVT10216, potent, selective, reversible, inhibitors, inhibits, aldehyde, dehydrogenase, 2, ALDH2, anxiolytics, anti-anxiety, Aldehyde, Dehydrogenase, Aldehyde, Dehydrogenase, Tocris Bioscience
Citations for CVT 10216
Citations are publications that use Tocris products.
Currently there are no citations for CVT 10216. Do you know of a great paper that uses CVT 10216 from Tocris? If so please let us know.
Reviews for CVT 10216
There are currently no reviews for this product. Be the first to review CVT 10216 and earn rewards!
Have you used CVT 10216?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)New
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells