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Biological Activity for WIN 18446
WIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.
Technical Data for WIN 18446
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WIN 18446
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for WIN 18446
The following data is based on the product molecular weight 366.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.73 mL||13.66 mL||27.31 mL|
|5 mM||0.55 mL||2.73 mL||5.46 mL|
|10 mM||0.27 mL||1.37 mL||2.73 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References for WIN 18446
References are publications that support the biological activity of the product.
Amory et al (2011) Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 32 111 PMID: 20705791
Hogarth et al (2011) Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 84 957 PMID: 21209416
If you know of a relevant reference for WIN 18446, please let us know.
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Keywords: WIN 18446, WIN 18446 supplier, WIN18446, spermatogenesis, inhibitors, inhibits, aldehyde, dehydrogenases, ALDH1a2, Aldehyde, Dehydrogenase, 4736, Tocris Bioscience
4 Citations for WIN 18446
Citations are publications that use Tocris products. Selected citations for WIN 18446 include:
Ana-Maria et al (2022) Epithelial colonization by gut dendritic cells promotes their functional diversification. Immunity 55 129-144.e8 PMID: 34910930
Corinne et al (2020) PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment. Elife 9 PMID: 33047671
Martine et al (2017) Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis. Sci Rep 7 17759 PMID: 29259204
Barrionuevo et al (2016) Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration. Elife 5 PMID: 27328324
Do you know of a great paper that uses WIN 18446 from Tocris? Please let us know.
Reviews for WIN 18446
Average Rating: 4 (Based on 1 Review.)
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This was used to inhibit recombinant Aldh1a2 activity in a titration curve.
Win-18446 showed an IC50 value at approximately 15 uM in a cell-free reaction assay. Was dissolved in DMSO to 100 mM with no solubility issues.