WIN 18446

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Cat.No. 4736 - WIN 18446 | C12H20Cl4N2O2 | CAS No. 1477-57-2
Description: ALDH1a2 inhibitor
Chemical Name: N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.

Technical Data

M. Wt 366.11
Formula C12H20Cl4N2O2
Storage Store at +4°C
CAS Number 1477-57-2
PubChem ID 15134
InChI Key FAOMZVDZARKPFJ-UHFFFAOYSA-N
Smiles ClC(Cl)C(NCCCCCCCCNC(C(Cl)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.61 100
ethanol 7.32 20

Preparing Stock Solutions

The following data is based on the product molecular weight 366.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.66 mL 27.31 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References

References are publications that support the products' biological activity.

Amory et al (2011) Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 32 111 PMID: 20705791

Hogarth et al (2011) Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 84 957 PMID: 21209416


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