Dehydrogenases are oxidoreductase enzymes. They catalyze the oxidation of a substrate through the transfer of hydrogen (hydride) to an acceptor (or co-enzyme). Dehydrogenases are classified according to the donor group, e.g. alcohol or aldehyde, and the acceptor. Acceptors include nicotinamide adenine dinucleotide (NAD+ or NADH), nicotinamide adenine dinucleotide phosphate (NADP+ or NADPH), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and cytochromes. Dehydrogenase enzymes are important in multiple physiological processes, including normal cellular metabolism as part of the TCA (Krebs) cycle, or in cancer metabolism in the glycolysis pathway.

Enzyme Data

Dehydrogenase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
11-HSD Human HSD11B1 NM_005525 P28845
Mouse Hsd11b1 NM_008288 P50172
Rat Hsd11b1 NM_017080 Q6TUH9
DHODH Human DHODH NM_001361 Q02127
Mouse Dhodh NM_020046 O35435
Rat Dhodh NM_001008553 Q63707
IMP1 Human IMPDH1 NM_000883 P20839
Mouse Impdh1 NM_011829 P50096
Rat Impdh1 NM_001108619 XP_342651
IMP2 Human IMPDH2 NM_000884 P12268
Mouse Impdh2 NM_011830 P24547
Rat Impdh2 NM_199099 Q6P9U9
PDHα1 Human PDHA1 NM_000284 P08559
Mouse Pdha1 NM_008810 P35486
Rat Pdha1 NM_001004072 P26284
PDHα2 Human PDHA2 NM_005390 P29803
Mouse Pdha2 NM_008811 P35487
Rat Pdha2 NM_053994 Q06437
PDHβ Human PDHB NM_000925 P11177
Mouse Pdhb NM_024221 Q9D051
Rat Pdhb NM_001007620 P49432