AS 19

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Cat.No. 1968 - AS 19 | C18H25N3 | CAS No. 1000578-26-6
Description: Potent 5-HT7 agonist
Chemical Name: (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo.

Technical Data

M. Wt 283.41
Formula C18H25N3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 1000578-26-6
PubChem ID 23642275
InChI Key BTTOYOKCLDAHHO-HNNXBMFYSA-N
Smiles CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.34 100
ethanol 28.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 283.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.64 mL 35.28 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Perez-Garcia and Meneses (2005) Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 163 136 PMID: 15936093

Perez-Garcia et al (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav.Brain Res. 169 83 PMID: 16480781

Horiguchi et al (2011) The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J.Pharmacol.Exp.Ther. 338 605 PMID: 21558435


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Keywords: AS 19, supplier, potent, 5-HT7, agonists, serotonin, receptors, 5-Hydroxytryptamine, agonist, AS19, 5-HT7, Receptors, 5-HT7, Receptors, Tocris Bioscience

1 Citation for AS 19

Citations are publications that use Tocris products. Selected citations for AS 19 include:

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Neuropsychopharmacology 3 e00103 PMID: 25692021


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