AS 19

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Description: Potent 5-HT7 agonist
Chemical Name: (2S)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin
Purity: ≥98% (HPLC)
Citations (4)
Reviews (1)
Literature (2)

Biological Activity for AS 19

AS 19 is a potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo. AS 19 also promotes melanin synthesis in B16F10 murine melanoma cells.

Technical Data for AS 19

M. Wt 283.41
Formula C18H25N3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 1000578-26-6
PubChem ID 23642275
Smiles CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AS 19

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 28.34 100
DMSO 28.34 100

Preparing Stock Solutions for AS 19

The following data is based on the product molecular weight 283.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.64 mL 35.28 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets for AS 19

Certificate of Analysis / Product Datasheet
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References for AS 19

References are publications that support the biological activity of the product.

Perez-Garcia and Meneses (2005) Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 163 136 PMID: 15936093

Perez-Garcia et al (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav.Brain Res. 169 83 PMID: 16480781

Horiguchi et al (2011) The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J.Pharmacol.Exp.Ther. 338 605 PMID: 21558435

Tang et al (2023) Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways. FASEB J. 37 e22893 PMID: 36961387

If you know of a relevant reference for AS 19, please let us know.

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Keywords: AS 19, AS 19 supplier, potent, 5-HT7, agonists, serotonin, receptors, 5-Hydroxytryptamine, agonist, AS19, melanogenesis, melanin, synthesis, anti-amnesic, Receptors, 1968, Tocris Bioscience

4 Citations for AS 19

Citations are publications that use Tocris products. Selected citations for AS 19 include:

Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Neuropsychopharmacology 3 e00103 PMID: 25692021

Tang et al (2023) Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways FASEB J 37 e22893

Domínguez-Soto (2017) Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis. Sci Rep 7 14761 PMID: 29116249

Do you know of a great paper that uses AS 19 from Tocris? Please let us know.

Reviews for AS 19

Average Rating: 5 (Based on 1 Review.)

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5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
Assay Type: In Vivo
Species: Rat

AS19 (5-HT7) and concentration(0.0001 mol/L)

PMID: 25692021
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.