You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 283.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.53 mL||17.64 mL||35.28 mL|
|5 mM||0.71 mL||3.53 mL||7.06 mL|
|10 mM||0.35 mL||1.76 mL||3.53 mL|
|50 mM||0.07 mL||0.35 mL||0.71 mL|
References are publications that support the biological activity of the product.
Perez-Garcia and Meneses (2005) Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 163 136 PMID: 15936093
Perez-Garcia et al (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav.Brain Res. 169 83 PMID: 16480781
Horiguchi et al (2011) The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J.Pharmacol.Exp.Ther. 338 605 PMID: 21558435
If you know of a relevant reference for AS 19, please let us know.
View Related Products by Product Action
Keywords: AS 19, AS 19 supplier, potent, 5-HT7, agonists, serotonin, receptors, 5-Hydroxytryptamine, agonist, AS19, Receptors, 1968, Tocris Bioscience
3 Citations for AS 19
Citations are publications that use Tocris products. Selected citations for AS 19 include:
Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517
Domínguez-Soto (2017) Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis. Sci Rep 7 14761 PMID: 29116249
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Neuropsychopharmacology 3 e00103 PMID: 25692021
Do you know of a great paper that uses AS 19 from Tocris? Please let us know.
Reviews for AS 19
Average Rating: 5 (Based on 1 Review.)
Have you used AS 19?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
AS19 (5-HT7) and concentration(0.0001 mol/L)
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.