5-Carboxamidotryptamine maleate

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Description: 5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7
Alternative Names: AH-21467,5-CT
Purity: ≥99% (HPLC)
Citations (14)
Literature (2)

Biological Activity for 5-Carboxamidotryptamine maleate

5-Carboxamidotryptamine maleate is a 5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B, 5-HT1D, 5-ht5 and 5-HT7 receptors.

Technical Data for 5-Carboxamidotryptamine maleate

M. Wt 319.32
Formula C11H13N3O.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 74885-72-6
PubChem ID 11709509
Smiles OC(=O)\C=C/C(O)=O.NCCC1=CNC2=CC=C(C=C12)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 5-Carboxamidotryptamine maleate

Solvent Max Conc. mg/mL Max Conc. mM
water 31.93 100

Preparing Stock Solutions for 5-Carboxamidotryptamine maleate

The following data is based on the product molecular weight 319.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets for 5-Carboxamidotryptamine maleate

Certificate of Analysis / Product Datasheet
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References for 5-Carboxamidotryptamine maleate

References are publications that support the biological activity of the product.

Beer et al (1992) An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatr. in the central nervous system of seven species. Eur.J.Pharmacol. 213 193 PMID: 1325915

Nowak et al (1993) [3H]-5-carboxamidotryptamine labels 5HT1D binding sites in bovine substantia nigra. Br.J.Pharmacol. 109 1206 PMID: 8401931

Zifa and Fillion (1992) 5-Hydroxytryptamine receptors. Pharmacol.Rev. 44 401 PMID: 1359584

Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1 PMID: 10822046

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View Related Products by Product Action

View all Non-selective 5-HT1 Agonists

Keywords: 5-Carboxamidotryptamine maleate, 5-Carboxamidotryptamine maleate supplier, high, affinity, 5ht5A, 5-HT7, 5-HT1, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, 5-ht5, Non-Selective, AH21467, AH-21467, 5-CT, Non-selective, 0458, Tocris Bioscience

14 Citations for 5-Carboxamidotryptamine maleate

Citations are publications that use Tocris products. Selected citations for 5-Carboxamidotryptamine maleate include:

Manzke et al (2009) Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci 364 2589 PMID: 19651659

Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453 PMID: 19649285

Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282

Morecroft et al (1999) 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. J Immunol 128 730 PMID: 10516655

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Seeburg et al (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci 24 10950 PMID: 15574745

Maclean and Morecroft (2001) Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br J Pharmacol 134 614 PMID: 11588116

Bijata et al (2017) Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix Cell Rep 19 1767 PMID: 28564597

Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. PLoS One 22 42 PMID: 26076928

Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. Br J Pharmacol 10 e0140369 PMID: 26460748

Chan et al (2016) A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. PLoS Pathog 12 e1005651 PMID: 27187180

Sargin et al (2016) Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels Elife 5 e21416 PMID: 27874831

Kim et al (2013) Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. Neuron 190 4795 PMID: 23554310

Gantz et al (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Am J Physiol Renal Physiol 78 807 PMID: 23764286

Do you know of a great paper that uses 5-Carboxamidotryptamine maleate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.