5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B, 5-HT1D, 5-ht5 and 5-HT7 receptors.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|phosphate buffered saline||15.97||50|
Preparing Stock Solutions
The following data is based on the product molecular weight 319.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.13 mL||15.66 mL||31.32 mL|
|5 mM||0.63 mL||3.13 mL||6.26 mL|
|10 mM||0.31 mL||1.57 mL||3.13 mL|
|50 mM||0.06 mL||0.31 mL||0.63 mL|
References are publications that support the products' biological activity.
Beer et al (1992) An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species. Eur.J.Pharmacol. 213 193 PMID: 1325915
Nowak et al (1993) [3H]-5-carboxamidotryptamine labels 5HT1D binding sites in bovine substantia nigra. Br.J.Pharmacol. 109 1206 PMID: 8401931
Zifa and Fillion (1992) 5-Hydroxytryptamine receptors. Pharmacol.Rev. 44 401 PMID: 1359584
Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1 PMID: 10822046
If you know of a relevant reference for 5-Carboxamidotryptamine maleate, please let us know.
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Keywords: 5-Carboxamidotryptamine maleate, supplier, high, affinity, 5ht5A, 5-HT7, 5-HT1, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, 5-ht5, Non-Selective, AH21467, AH-21467, 5-CT, Non-selective, 5-HT1, 5-HT7, Receptors, 5-ht5, Receptors, Non-selective, 5-HT1, Tocris Bioscience
9 Citations for 5-Carboxamidotryptamine maleate
Citations are publications that use Tocris products. Selected citations for 5-Carboxamidotryptamine maleate include:
Bijata et al (2017) Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix Cell Rep 19 1767 PMID: 28564597
Sargin et al (2016) Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels Elife 5 e21416 PMID: 27874831
Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. PLoS One 22 42 PMID: 26076928
Kim et al (2013) Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. Neuron 190 4795 PMID: 23554310
Gantz et al (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Am J Physiol Renal Physiol 78 807 PMID: 23764286
Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. Br J Pharmacol 10 e0140369 PMID: 26460748
Manzke et al (2009) Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci 364 2589 PMID: 19651659
Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453 PMID: 19649285
Morecroft et al (1999) 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. J Immunol 128 730 PMID: 10516655
Do you know of a great paper that uses 5-Carboxamidotryptamine maleate from Tocris? If so please let us know.
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