5-Carboxamidotryptamine maleate

Pricing Availability Delivery Time Qty
Cat.No. 0458 - 5-Carboxamidotryptamine maleate | C11H13N3O.C4H4O4 | CAS No. 74885-72-6
Description: 5-HT1 agonist. Also has high affinity for 5-ht5a and 5-HT7
Alternative Names: AH-21467, 5-CT
Purity: ≥99% (HPLC)
Datasheet
Citations (8)
Literature

Biological Activity

5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B, 5-HT1D, 5-ht5 and 5-HT7 receptors.

Technical Data

M. Wt 319.32
Formula C11H13N3O.C4H4O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 74885-72-6
PubChem ID 11709509
InChI Key PZQZSWAOVAMBQM-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.NCCC1=CNC2=CC=C(C=C12)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 15.97 50
water 31.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 319.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Beer et al (1992) An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species. Eur.J.Pharmacol. 213 193 PMID: 1325915

Nowak et al (1993) [3H]-5-carboxamidotryptamine labels 5HT1D binding sites in bovine substantia nigra. Br.J.Pharmacol. 109 1206 PMID: 8401931

Zifa and Fillion (1992) 5-Hydroxytryptamine receptors. Pharmacol.Rev. 44 401 PMID: 1359584

Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1 PMID: 10822046


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View Related Products by Product Action

View all Non-selective 5-HT1 Agonists

Keywords: 5-Carboxamidotryptamine maleate, supplier, high, affinity, 5ht5A, 5-HT7, 5-HT1, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, 5-ht5, Non-Selective, AH21467, AH-21467, 5-CT, Non-selective, 5-HT1, 5-HT7, Receptors, 5-ht5, Receptors, Non-selective, 5-HT1, Tocris Bioscience

8 Citations for 5-Carboxamidotryptamine maleate

Citations are publications that use Tocris products. Selected citations for 5-Carboxamidotryptamine maleate include:

Kim et al (2013) Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. Neuron 190 4795 PMID: 23554310

Gantz et al (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Am J Physiol Renal Physiol 78 807 PMID: 23764286

Manzke et al (2009) Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci 364 2589 PMID: 19651659

Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453 PMID: 19649285

Morecroft et al (1999) 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. J Immunol 128 730 PMID: 10516655

Sargin et al (2016) Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels Elife 5 e21416 PMID: 27874831

Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. PLoS One 22 42 PMID: 26076928

Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. Br J Pharmacol 10 e0140369 PMID: 26460748


Do you know of a great paper that uses 5-Carboxamidotryptamine maleate from Tocris? If so please let us know.

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