LY 344864 hydrochloride

Pricing Availability   Qty
Description: Potent and selective 5-HT1F agonist
Chemical Name: N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity for LY 344864 hydrochloride

LY 344864 hydrochloride is a potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

Licensing Information

Sold under license from Eli Lilly and Company

Compound Libraries for LY 344864 hydrochloride

LY 344864 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 344864 hydrochloride

M. Wt 387.88
Formula C21H22N3OF.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1217756-94-9
PubChem ID 56972176
Smiles Cl[H].CN(C)[C@@H]1CCC2=C(C1)C1=CC(NC(=O)C3=CC=C(F)C=C3)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 344864 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 19.39 50
DMSO 38.79 100

Preparing Stock Solutions for LY 344864 hydrochloride

The following data is based on the product molecular weight 387.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.89 mL 25.78 mL
5 mM 0.52 mL 2.58 mL 5.16 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets for LY 344864 hydrochloride

Certificate of Analysis / Product Datasheet
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References for LY 344864 hydrochloride

References are publications that support the biological activity of the product.

Ramadan et al (2003) 5-HT1F receptor agonists in acute migraine treatment: a hypothesis. Cephalalgia 23 776 PMID: 14510923

Goadsby and Classey (2003) Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input. Neuroscience 122 491 PMID: 14614913

Lee et al (1997) Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Science 61 2117

If you know of a relevant reference for LY 344864 hydrochloride, please let us know.

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3 Citations for LY 344864 hydrochloride

Citations are publications that use Tocris products. Selected citations for LY 344864 hydrochloride include:

Scholpa et al (2018) 5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease. Br J Pharmacol 175 348 PMID: 29057453

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Garrett et al (2014) Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther 350 257 PMID: 24849926

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.