MAPK Family

MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

MAPK Family Target Files

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MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

View pathway or download PDF

Six groups of MAPK have so far been identified:

  1. Extracellular signal-regulated kinases (ERK1, ERK2).
  2. c-Jun N-terminal kinases (JNKs)
  3. p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14)
  4. ERK5 (MAPK7)
  5. ERK3 (MAPK6) and ERK4 (MAPK4)
  6. ERK7/8 (MAPK15)

ERK 1 and ERK 2 transduce signals from growth factors and are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38 MAPKs (α-, β-, δ and γ- isoforms) are activated by UV irradiation, inflammatory cytokines and hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and inflammation (p38).

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Cancer Research Product Guide

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Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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MAPK Signaling Scientific Review

Our MAPK signaling review gives an overview of the MAPK signaling cascade and summarizes small molecule inhibitors of the pathway. Request copy or view PDF today.

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Learning and Memory

Written by Clea Warburton and Zafar Bashir

Learning & Memory Life Science Poster

Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request copy or view PDF today.

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MAPK Pathway

MAPK Signaling Pathway

The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.

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Neuroscience 2016

Neuroscience 2016

November 12 - 16, 2016

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