SB 202190

Cat. No. 1264

SB 202190 C20H14N3OF [152121-30-7]

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Chemical Name: 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol

Biological Activity

A highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Also available as part of the MAPK Inhibitor Tocriset™.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
331.35
Formula:
C20H14N3OF
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
152121-30-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Gafni et al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282. PMID: 24172903.

Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. PMID: 10998351.

Frantz et al (1998) The activation of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding. Biochemistry 37 13846. PMID: 9753474.

Nemoto et al (1998) Induction of apoptosis by SB 202190 through inhibition of p38β mitogen-activated protein kinase. J.Biol.Chem. 273 16415. PMID: 9632706.

Jiang et al (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J.Biol.Chem. 271 17920. PMID: 8663524.

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Citations are publications that use Tocris products. Selected citations for SB 202190 include:

Babu et al (2014) TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer 14 113. PMID: 24555435.

Toutounchian et al (2014) Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK. PLoS One 9 e100210. PMID: 24956278.

Nicastro et al (2013) 3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells. J Nutr Biochem 24 1882. PMID: 23968581.

Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638. PMID: 23792643.

Guillemot and Citi (2006) Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Mol Biol Cell 17 3569. PMID: 16723500.

Montero et al (2004) Calcineurin-independent inhibition of mitochondrial Ca2+ uptake by cyclosporin A. Br J Pharmacol 141 263. PMID: 14691054.

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Keywords: SB 202190, supplier, Potent, selective, inhibitors, inhibits, p38, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, SB202190, GlaxoSmithKline, GSK, organoids, Tocris Bioscience, p38 MAPK Inhibitor products

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