Methylmalonate

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Cat.No. 4979 - Methylmalonate | C4H6O4 | CAS No. 516-05-2
Description: Succinate dehydrogenase inhibitor
Chemical Name: 2-Methylpropanedioic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Intracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.

Technical Data

M. Wt 118.09
Formula C4H6O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 516-05-2
PubChem ID 487
InChI Key ZIYVHBGGAOATLY-UHFFFAOYSA-N
Smiles OC(C(C)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 11.81 100
DMSO 11.81 100
ethanol 11.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 118.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.47 mL 42.34 mL 84.68 mL
5 mM 1.69 mL 8.47 mL 16.94 mL
10 mM 0.85 mL 4.23 mL 8.47 mL
50 mM 0.17 mL 0.85 mL 1.69 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Beal and Ferrante (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 5 373 PMID: 15100720

McLaughlin et al (1998) Methylmalonate toxicity in primary neuronal cultures. Neuroscience 86 279 PMID: 9692761

Ehrlich (2012) Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 9 270 PMID: 22441874


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Keywords: methylmalonate succinate dehydrogenase inhibitors inhibits malonate Huntingtons disease HD mitochondrial toxins Other Dehydrogenases

Citations for Methylmalonate

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Methylmalonate

Protocols

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