Intracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 118.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||8.47 mL||42.34 mL||84.68 mL|
|5 mM||1.69 mL||8.47 mL||16.94 mL|
|10 mM||0.85 mL||4.23 mL||8.47 mL|
|50 mM||0.17 mL||0.85 mL||1.69 mL|
References are publications that support the products' biological activity.
Beal and Ferrante (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 5 373 PMID: 15100720
McLaughlin et al (1998) Methylmalonate toxicity in primary neuronal cultures. Neuroscience 86 279 PMID: 9692761
Ehrlich (2012) Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 9 270 PMID: 22441874
If you know of a relevant reference for Methylmalonate, please let us know.
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Keywords: Methylmalonate, supplier, methylmalonate, succinate, dehydrogenase, inhibitors, inhibits, malonate, Huntingtons, disease, HD, mitochondrial, toxins, Other, Dehydrogenases, Oxidative, Phosphorylation, Other, Dehydrogenases, Tocris Bioscience
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