Intracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 118.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||8.47 mL||42.34 mL||84.68 mL|
|5 mM||1.69 mL||8.47 mL||16.94 mL|
|10 mM||0.85 mL||4.23 mL||8.47 mL|
|50 mM||0.17 mL||0.85 mL||1.69 mL|
References are publications that support the biological activity of the product.
Beal and Ferrante (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 5 373 PMID: 15100720
McLaughlin et al (1998) Methylmalonate toxicity in primary neuronal cultures. Neuroscience 86 279 PMID: 9692761
Ehrlich (2012) Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 9 270 PMID: 22441874
If you know of a relevant reference for Methylmalonate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Methylmalonate, Methylmalonate supplier, methylmalonate, succinate, dehydrogenase, inhibitors, inhibits, malonate, Huntingtons, disease, HD, mitochondrial, toxins, Other, Dehydrogenases, Oxidative, Phosphorylation, 4979, Tocris Bioscience
Citations for Methylmalonate
Citations are publications that use Tocris products.
Currently there are no citations for Methylmalonate. Do you know of a great paper that uses Methylmalonate from Tocris? Please let us know.
Reviews for Methylmalonate
There are currently no reviews for this product. Be the first to review Methylmalonate and earn rewards!
Have you used Methylmalonate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells