FCCP

Pricing Availability Delivery Time Qty
Cat.No. 0453 - FCCP | C10H5F3N4O | CAS No. 370-86-5
Description: Oxidative phosphorylation uncoupler
Chemical Name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

A very potent uncoupler of oxidative phosphorylation in mitochondria.

Technical Data

M. Wt 254.17
Formula C10H5F3N4O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 370-86-5
PubChem ID 3330
InChI Key BMZRVOVNUMQTIN-UHFFFAOYSA-N
Smiles N#CC(C#N)=NNC1=CC=C(OC(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.34 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Connop et al (1999) Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J.Neurochem. 72 1457 PMID: 10098849

Heytler and Pritchard (1962) A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 7 272 PMID: 13907155


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Keywords: FCCP, supplier, Oxidative, phosphorylation, uncoupler, Oxidative, Phosphorylation, Tocris Bioscience

3 Citations for FCCP

Citations are publications that use Tocris products. Selected citations for FCCP include:

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Choubey et al (2014) BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy 10 1105 PMID: 24879156

Gerich et al (2009) H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. J Pharmacol Exp Ther 458 937 PMID: 19430810


Do you know of a great paper that uses FCCP from Tocris? If so please let us know.

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Enzymes
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  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for FCCP

Protocols

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