FCCP

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Cat.No. 0453 - FCCP | C10H5F3N4O | CAS No. 370-86-5
Description: Oxidative phosphorylation uncoupler
Chemical Name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Purity: ≥99% (HPLC)
Datasheet
Citations (8)
Reviews
Literature

Biological Activity

A very potent uncoupler of oxidative phosphorylation in mitochondria.

Technical Data

M. Wt 254.17
Formula C10H5F3N4O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 370-86-5
PubChem ID 3330
InChI Key BMZRVOVNUMQTIN-UHFFFAOYSA-N
Smiles N#CC(C#N)=NNC1=CC=C(OC(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.34 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Connop et al (1999) Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J.Neurochem. 72 1457 PMID: 10098849

Heytler and Pritchard (1962) A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 7 272 PMID: 13907155


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Keywords: FCCP, FCCP supplier, Oxidative, phosphorylation, uncoupler, Phosphorylation, 0453, Tocris Bioscience

8 Citations for FCCP

Citations are publications that use Tocris products. Selected citations for FCCP include:

Choubey et al (2014) BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy 10 1105 PMID: 24879156

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Janc (2014) The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome. Front Cell Neurosci 8 56 PMID: 24605086

Hogan et al (2014) Divergent effects of painful nerve injury on mitochondrial Ca(2+) buffering in axotomized and adjacent sensory neurons. Brain Res 1589 112 PMID: 25251590

Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329

Burt et al (2013) 9-Phenanthrol and flufenamic acid inhibit calcium oscillations in HL-1 mouse cardiomyocytes. Cell Calcium 54 193 PMID: 23831210

Mané and Müller (2012) Temporo-spectral imaging of intrinsic optical signals during hypoxia-induced spreading depression-like depolarization. PLoS One 7 e43981 PMID: 22952835

Gerich et al (2009) H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. J Pharmacol Exp Ther 458 937 PMID: 19430810


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Literature in this Area

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