CCCP

Pricing Availability Delivery Time Qty
Cat.No. 0452 - CCCP | C9H5ClN4 | CAS No. 555-60-2
Description: Oxidative phosphorylation uncoupler
Chemical Name: Carbonyl cyanide 3-chlorophenylhydrazone
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Widely used uncoupler of oxidative phosphorylation.

Technical Data

M. Wt 204.62
Formula C9H5ClN4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 555-60-2
PubChem ID 2603
InChI Key UGTJLJZQQFGTJD-UHFFFAOYSA-N
Smiles ClC1=CC=CC(NN=C(C#N)C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.46 100

Preparing Stock Solutions

The following data is based on the product molecular weight 204.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.89 mL 24.44 mL 48.87 mL
5 mM 0.98 mL 4.89 mL 9.77 mL
10 mM 0.49 mL 2.44 mL 4.89 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Heytler and Pritchard (1962) A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 7 272 PMID: 13907155


If you know of a relevant reference for CCCP, please let us know.

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Keywords: Oxidative phosphorylation uncoupler Oxidative Phosphorylation

3 Citations for CCCP

Citations are publications that use Tocris products. Selected citations for CCCP include:

Guo et al (2015) Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways. Curr Protoc Chem Biol 7 141 PMID: 26331525

Choubey et al (2014) BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy 10 1105 PMID: 24879156

Chouhan et al (2010) Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ but exert little influence as Ca2+ buffers at nerve firing rates in situ. J Neurosci 30 1869 PMID: 20130196


Do you know of a great paper that uses CCCP from Tocris? If so please let us know.

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
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  • Signal Transduction
  • Stem Cells

Pathways for CCCP

Protocols

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