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BAM 15

Cat. No. 5737 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Mitochondrial protonophore uncoupler
Chemical Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BAM 15

BAM 15 is a mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.

Compound Libraries for BAM 15

BAM 15 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAM 15

M. Wt 340.29
Formula C16H10F2N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 210302-17-3
PubChem ID 565708
InChI Key OEGJBRZAJRPPHL-UHFFFAOYSA-N
Smiles FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAM 15

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.03 100

Preparing Stock Solutions for BAM 15

The following data is based on the product molecular weight 340.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.39 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets for BAM 15

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for BAM 15

References are publications that support the biological activity of the product.

Kenwood et al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858 PMID: 26119501

Kenwood et al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114 PMID: 24634817

Axelrod et al (2020) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol.Med. doi: 10.15252 PMID: 32519812

If you know of a relevant reference for BAM 15, please let us know.

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Keywords: BAM 15, BAM 15 supplier, BAM15, mitochondrial, uncouplers, oxidative, phosphorylation, respiration, protonophores, renal, ischemic-reperfusion, injury, Oxidative, Phosphorylation, 5737, Tocris Bioscience

3 Citations for BAM 15

Citations are publications that use Tocris products. Selected citations for BAM 15 include:

Panja et al (2019) Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol 45 141 PMID: 29679372

Wei et al (2018) iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications. Cell 173 851-863.e16 PMID: 29576452

Styr et al (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102 1009 PMID: 31047779

Do you know of a great paper that uses BAM 15 from Tocris? Please let us know.

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Literature in this Area

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