BAM 15

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Cat.No. 5737 - BAM 15 | C16H10F2N6O | CAS No. 210302-17-3
Description: Mitochondrial protonophore uncoupler
Chemical Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Purity: ≥98% (HPLC)

Biological Activity

Mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.

Technical Data

M. Wt 340.29
Formula C16H10F2N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 210302-17-3
PubChem ID 565708
Smiles FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 340.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.39 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Kenwood et al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858 PMID: 26119501

Kenwood et al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114 PMID: 24634817

If you know of a relevant reference for BAM 15, please let us know.

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Keywords: BAM 15, BAM 15 supplier, BAM15, mitochondrial, uncouplers, oxidative, phosphorylation, respiration, protonophores, renal, ischemic-reperfusion, injury, Oxidative, Phosphorylation, 5737, Tocris Bioscience

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