BAM 15
Biological Activity
Mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.
Technical Data
| M. Wt | 340.29 |
| Formula | C16H10F2N6O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 210302-17-3 |
| PubChem ID | 565708 |
| InChI Key | OEGJBRZAJRPPHL-UHFFFAOYSA-N |
| Smiles | FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 340.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.69 mL | 29.39 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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References
References are publications that support the products' biological activity.
Kenwood et al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858 PMID: 26119501
Kenwood et al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114 PMID: 24634817
If you know of a relevant reference for BAM 15, please let us know.
View Related Products by Target
Keywords: BAM15 mitochondrial uncouplers oxidative phosphorylation respiration protonophores renal ischemic-reperfusion injury Oxidative Phosphorylation
Citations for BAM 15
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Literature in this Area
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