BAM 15
Biological Activity
Mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.
Technical Data
M. Wt | 340.29 |
Formula | C16H10F2N6O |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 210302-17-3 |
PubChem ID | 565708 |
InChI Key | OEGJBRZAJRPPHL-UHFFFAOYSA-N |
Smiles | FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 340.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.94 mL | 14.69 mL | 29.39 mL |
5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Kenwood et al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858 PMID: 26119501
Kenwood et al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114 PMID: 24634817
If you know of a relevant reference for BAM 15, please let us know.
View Related Products by Target
Keywords: BAM 15, supplier, BAM15, mitochondrial, uncouplers, oxidative, phosphorylation, respiration, protonophores, renal, ischemic-reperfusion, injury, Oxidative, Phosphorylation, Oxidative, Phosphorylation, Tocris Bioscience
Citations for BAM 15
Citations are publications that use Tocris products.
Currently there are no citations for BAM 15. Do you know of a great paper that uses BAM 15 from Tocris? If so please let us know.
Reviews for BAM 15
There are currently no reviews for this product. Be the first to review BAM 15 and earn rewards!
Have you used BAM 15?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and Europe
Submit a ReviewLiterature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)New
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Aptamers
- Cell Metabolism
- Epigenetics
- Fluorescent Imaging
- Signal Transduction
- Stem Cells