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Submit ReviewBAM 15
Description: Mitochondrial protonophore uncoupler
Chemical Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Purity: ≥98% (HPLC)
Biological Activity
Mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.
Compound Libraries
BAM 15 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 340.29 |
| Formula | C16H10F2N6O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 210302-17-3 |
| PubChem ID | 565708 |
| InChI Key | OEGJBRZAJRPPHL-UHFFFAOYSA-N |
| Smiles | FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 340.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.69 mL | 29.39 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Kenwood et al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858 PMID: 26119501
Kenwood et al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114 PMID: 24634817
Axelrod et al (2020) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol.Med. doi: 10.15252 PMID: 32519812
If you know of a relevant reference for BAM 15, please let us know.
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Keywords: BAM 15, BAM 15 supplier, BAM15, mitochondrial, uncouplers, oxidative, phosphorylation, respiration, protonophores, renal, ischemic-reperfusion, injury, Oxidative, Phosphorylation, 5737, Tocris Bioscience
2 Citations for BAM 15
Citations are publications that use Tocris products. Selected citations for BAM 15 include:
Styr et al (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102 1009 PMID: 31047779
Panja et al (2019) Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol 45 141 PMID: 29679372
Do you know of a great paper that uses BAM 15 from Tocris? Please let us know.
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