CCT 018159

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Cat.No. 2435 - CCT 018159 | C20H20N2O4 | CAS No. 171009-07-7
Description: Hsp90 inhibitor
Chemical Name: 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol
Purity: ≥98% (HPLC)
Datasheet
Citations

Biological Activity

Novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC50 = 5.7 μM) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG (Cat. No. 1515) and is independent of NQO1/DT-diaphorase and P-glycoprotein expression.

Compound Libraries

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Technical Data

M. Wt 352.39
Formula C20H20N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 171009-07-7
PubChem ID 5327091
InChI Key BBTMGPQSLSYPHE-ZHZULCJRSA-N
Smiles CCC1=C(O)C=C(O)C(=C1)C1=NNC(C)=C1C1=CC2=C(OCCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.24 100
ethanol 35.24 100
water 1.76 5

Preparing Stock Solutions

The following data is based on the product molecular weight 352.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cheung et al (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg.Med.Chem.Lett. 15 3338 PMID: 15955698

Dymock et al (2005) Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J.Med.Chem. 48 4212 PMID: 15974572

Sharp et al (2007) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res. 67 2206 PMID: 17332351


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Keywords: Hsp90 inhibitors inhibits Heat Shock Protein 90 CCT018159 Hsp90

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