Complement

The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis, triggering inflammation and immune clearance.

Products
Background
Literature
Gene Data

Antagonists

Cat No Product Name / Activity
3333 NDT 9513727
Potent, selective human C5a receptor antagonist
5196 PMX 205
Potent C5a receptor peptide antagonist
5473 PMX 53
Potent C5a receptor antagonist
5455 W 54011
High affinity C5a receptor antagonist

Other

Cat No Product Name / Activity
2585 Compstatin
C3-binding protein, inhibits complement activation
3796 Compstatin control peptide
Control peptide for Compstatin (Cat. No. 2585)
5697 PMX 53c
Negative control for PMX 53 (Cat. No. 5473)

The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis, triggering inflammation and immune clearance.

There are three pathways that can activate the complement system; the classical complement pathway (in response to IgG- or IgM-antigen complexes), the alternative complement pathway (spontaneous activation) and the mannose-binding lectin pathway (in response to lectin residues on pathogen cell surface membranes). All three pathway generate variants of C3 convertase, which cleaves C3 into C3a and C3b. C3a and C3b activate a series of further cleavage events that activates the complement cascade. This leads to immune defence responses such as degranulation of mast cells, increasing vascular permeability and initiation of the membrane attack pathway.

Deregulation of the complement system would be extremely damaging to the host, so it is tightly regulated by complement control proteins. These regulatory proteins are found in much higher concentrations that complement proteins themselves and prevent complement system activation in 'self' tissues. The complement system has been implicated in many autoimmune disorders, including systemic lupus erythematosus, multiple sclerosis and arthritis, and more recently has been suggested to have a pathophysiological role in Alzheimer's and other neurodegenerative disorders.

Literature for Complement

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Complement Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
C1qα Human C1QA NM_015991 P02745
Mouse C1qa NM_007572 P98086
Rat C1qa NM_001008515 P31720
C1qβ Human C1QB NM_000491 P02746
Mouse C1qb NM_009777 P14106
Rat C1qb NM_019262 P31721
C1Qγ Human C1QC NM_172369 P02747
Mouse C1qc NM_007574 Q02105
Rat C1qc NM_001008524 P31722
C1r Human C1R NM_001733 P00736
Mouse C1r NM_023143 Q8CG16
Rat C1r NM_001134555 Q4G030
C1s Human C1S NM_001734 Q9UCV4
Mouse C1s NM_144938 Q8CG14
Rat C1s NM_138900 Q6P6T1
C2 Human C2 NM_000063 P06681
Mouse C2 NM_013484 P21180
Rat C2 NM_172222 Q8CIP8
C3 Human C3 NM_000064 P01024
Mouse C3 NM_009778 P01027
Rat C3 NM_016994 P01026
C4A Human C4A NM_007293 Q9NPK5
Mouse C4a NM_011413 NP_035543
C4B Human C4B NM_001002029 Q9UIP5
Mouse C4b NM_009780 NP_033910
Rat C4b NM_031504 P08649
C5 Human C5 NM_001735 P01031
Mouse Hc NM_010406 P06684
Rat C5 XM_345342 P08650
C6 Human C6 NM_000065 P13671
Mouse C6 NM_016704 NP_057913
Rat C6 NM_176074 Q811M5
C7 Human C7 NM_000587 P10643
Mouse C7 XM_356827 XP_356827
Rat C7 XM_226803 Q9ERF0
C8α Human C8A NM_000562 P07357
Mouse C8a NM_146148 Q8K182
Rat C8a NM_001106670 XP_233251
C8β Human C8B NM_000066 P07358
Mouse C8b NM_133882 Q8BH35
Rat C8b XM_233250 P55314
C8γ Human C8G NM_000606 P07360
Mouse C8g NM_027062 Q8VCG4
Rat C8g NM_001106555 XP_215990
C9 Human C9 NM_001737 P02748
Mouse C9 NM_013485 P06683
Rat C9 NM_057146 Q5BKC4
Complement factor B Human CFB NM_001710 P00751
Mouse Cfb NM_008198 P04186
Rat Cfb NM_212466 Q6MG74
Complement factor D Human CFD NM_001928 P00746
Mouse Cfd NM_013459 P03953
Rat Cfd NM_001077642 P32038
Complement factor H Human CFH NM_000186 Q9NU86
Mouse Cfh M12660 P06909
Rat Cfh NM_130409 Q5FVP9
Complement factor I Human CFI NM_000204 P05156
Mouse Cfi U47810 Q61129
Rat Cfi NM_024157 Q9WUW3
Complement factor properdin Human CFP NM_002621 P27918
Mouse Cfp NM_008823 P11680
Rat Cfp NM_001106757 XP_216784