High affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).
|Storage||Store at -20°C|
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 493.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.03 mL||10.14 mL||20.28 mL|
|5 mM||0.41 mL||2.03 mL||4.06 mL|
|10 mM||0.2 mL||1.01 mL||2.03 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
References are publications that support the products' biological activity.
Sumichika et al (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 277 49403 PMID: 12384495
Monk et al (2007) Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 152 429 PMID: 17603557
Cho et al (2014) Autocrine effects of tumor-derived complement. Cell Rep. 6 1085 PMID: 24613353
If you know of a relevant reference for W 54011, please let us know.
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Keywords: W 54011, supplier, W54011, high, affinity, C5a, receptors, antagonists, antagonism, neutrophils, complement, Complement, Complement, Tocris Bioscience
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