W 54011

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Description: High affinity C5a receptor antagonist
Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for W 54011

W 54011 is a high affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

Compound Libraries for W 54011

W 54011 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for W 54011

M. Wt 493.08
Formula C30H36N2O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 405098-33-1
PubChem ID 5311121
Smiles CC(C)C1=CC=C(N(CC2=CC=C(N(C)C)C=C2)C(C3C(C=C(OC)C=C4)=C4CCC3)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for W 54011

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.65 50

Preparing Stock Solutions for W 54011

The following data is based on the product molecular weight 493.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.06 mL 20.28 mL 40.56 mL
2.5 mM 0.81 mL 4.06 mL 8.11 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
25 mM 0.08 mL 0.41 mL 0.81 mL

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References for W 54011

References are publications that support the biological activity of the product.

Sumichika et al (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 277 49403 PMID: 12384495

Monk et al (2007) Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 152 429 PMID: 17603557

Cho et al (2014) Autocrine effects of tumor-derived complement. Cell Rep. 6 1085 PMID: 24613353

If you know of a relevant reference for W 54011, please let us know.

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Keywords: W 54011, W 54011 supplier, W54011, high, affinity, C5a, receptors, antagonists, antagonism, neutrophils, complement, Complement, 5455, Tocris Bioscience

2 Citations for W 54011

Citations are publications that use Tocris products. Selected citations for W 54011 include:

Sahu et al (2019) Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Rep 28 2567 PMID: 31484069

Trent M et al (2021) Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Mol Cell 81 4605-4621.e11 PMID: 34582793

Do you know of a great paper that uses W 54011 from Tocris? Please let us know.

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