W 54011

Pricing Availability   Qty
Cat.No. 5455 - W 54011 | C30H36N2O2.HCl | CAS No. 405098-33-1
Description: High affinity C5a receptor antagonist
Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

Compound Libraries

W 54011 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 493.08
Formula C30H36N2O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 405098-33-1
PubChem ID 5311121
InChI Key UKBJWRMNGCDKNL-UHFFFAOYSA-N
Smiles CC(C)C1=CC=C(N(CC2=CC=C(N(C)C)C=C2)C(C3C(C=C(OC)C=C4)=C4CCC3)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.65 50

Preparing Stock Solutions

The following data is based on the product molecular weight 493.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.06 mL 20.28 mL 40.56 mL
2.5 mM 0.81 mL 4.06 mL 8.11 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
25 mM 0.08 mL 0.41 mL 0.81 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Sumichika et al (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 277 49403 PMID: 12384495

Monk et al (2007) Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 152 429 PMID: 17603557

Cho et al (2014) Autocrine effects of tumor-derived complement. Cell Rep. 6 1085 PMID: 24613353


If you know of a relevant reference for W 54011, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Complement Antagonists

Keywords: W 54011, W 54011 supplier, W54011, high, affinity, C5a, receptors, antagonists, antagonism, neutrophils, complement, Complement, 5455, Tocris Bioscience

Citations for W 54011

Citations are publications that use Tocris products.

Currently there are no citations for W 54011. Do you know of a great paper that uses W 54011 from Tocris? Please let us know.

Reviews for W 54011

There are currently no reviews for this product. Be the first to review W 54011 and earn rewards!

Have you used W 54011?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation