Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons.
Control Peptide also available.
(Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1550.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.64 mL||3.22 mL||6.45 mL|
|5 mM||0.13 mL||0.64 mL||1.29 mL|
|10 mM||0.06 mL||0.32 mL||0.64 mL|
|50 mM||0.01 mL||0.06 mL||0.13 mL|
References are publications that support the biological activity of the product.
Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884 PMID: 8752942
Fiane et al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52 PMID: 10355733
Soulika et al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212 PMID: 10964539
If you know of a relevant reference for Compstatin, please let us know.
Keywords: Compstatin, Compstatin supplier, C3-binding, protein, inhibits, inhibitors, complement, activation, Convertase, Complement, 2585, Tocris Bioscience
4 Citations for Compstatin
Citations are publications that use Tocris products. Selected citations for Compstatin include:
Lee et al (2014) Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes. Cell Death Dis 5 e1192 PMID: 24763049
Magge et al (2013) Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther 20 342 PMID: 23661042
Yang et al (2009) Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome. Arterioscler Thromb Vasc Biol 29 1213 PMID: 19443843
Sun et al (2012) Is asthma related to choroidal neovascularization? Pharmacol Res Perspect 7 e35415 PMID: 22567103
Do you know of a great paper that uses Compstatin from Tocris? Please let us know.
Reviews for Compstatin
Average Rating: 4 (Based on 1 Review.)
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We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.
Literature in this Area
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