Compstatin

Pricing Availability Delivery Time Qty
Cat.No. 2585 - Compstatin | Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: 2 -12) | CAS No. 206645-99-0
Description: C3-binding protein, inhibits complement activation
Datasheet
Citations (4)
Reviews (1)
Literature

Biological Activity

Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons.

Control Peptide also available.

Technical Data

M. Wt 1550.77
Formula C66H99N23O17S2
Sequence ICVVQDWGHHRCT

(Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)

Storage Store at -20°C
CAS Number 206645-99-0
PubChem ID 25082538
InChI Key RDTRHBCZFDCUPW-KWICJJCGSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1550.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.22 mL 6.45 mL
5 mM 0.13 mL 0.64 mL 1.29 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884 PMID: 8752942

Fiane et al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52 PMID: 10355733

Soulika et al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212 PMID: 10964539


If you know of a relevant reference for Compstatin, please let us know.

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Keywords: Compstatin, Compstatin supplier, C3-binding, protein, inhibits, inhibitors, complement, activation, Convertase, Complement, 2585, Tocris Bioscience

4 Citations for Compstatin

Citations are publications that use Tocris products. Selected citations for Compstatin include:

Lee et al (2014) Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes. Cell Death Dis 5 e1192 PMID: 24763049

Magge et al (2013) Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther 20 342 PMID: 23661042

Yang et al (2009) Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome. Arterioscler Thromb Vasc Biol 29 1213 PMID: 19443843

Sun et al (2012) Is asthma related to choroidal neovascularization? Pharmacol Res Perspect 7 e35415 PMID: 22567103


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Reviews for Compstatin

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We have tested whether C3b can enzymatically degrade Amyloid Precursor Protein
By Ahsan Habib on 01/06/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: CHO/APPwt

We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.


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