Compstatin

Pricing Availability   Qty
Cat.No. 2585 - Compstatin | Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: 2-12) | CAS No. 206645-99-0
Description: C3-binding peptide; inhibits complement activation
Purity: ≥95% (HPLC)
Datasheet
Citations (6)
Reviews (1)
Literature (2)

Biological Activity for Compstatin

Compstatin is a complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.

Control Peptide also available.

Technical Data for Compstatin

M. Wt 1550.77
Formula C66H99N23O17S2
Sequence ICVVQDWGHHRCT

(Modifications: Thr-13 = C-terminal amide, Disulfide bridge: 2-12)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 206645-99-0
PubChem ID 25082538
InChI Key RDTRHBCZFDCUPW-KWICJJCGSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Compstatin

Solubility Soluble to 2 mg/ml in water

Product Datasheets for Compstatin

Certificate of Analysis / Product Datasheet
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References for Compstatin

References are publications that support the biological activity of the product.

Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884 PMID: 8752942

Fiane et al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52 PMID: 10355733

Soulika et al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212 PMID: 10964539


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Keywords: Compstatin, Compstatin supplier, C3-binding, protein, inhibits, inhibitors, complement, activation, Convertase, Complement, 2585, Tocris Bioscience

6 Citations for Compstatin

Citations are publications that use Tocris products. Selected citations for Compstatin include:

Koupenova et al (2019) The role of platelets in mediating a response to human influenza infection. Nat Commun 10 1780 PMID: 30992428

Magge et al (2013) Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther 20 342 PMID: 23661042

Yang et al (2009) Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the IF.-inducible immunoproteasome. Arterioscler Thromb Vasc Biol 29 1213 PMID: 19443843

Larsen et al (2019) Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG. Front Immunol 9 3088 PMID: 30666256


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Reviews for Compstatin

Average Rating: 4 (Based on 1 Review.)

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We have tested whether C3b can enzymatically degrade Amyloid Precursor Protein.
By Ahsan Habib on 01/06/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: CHO/APPwt

We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.


Literature in this Area

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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