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PMX 205

Cat. No. 5196 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Potent C5a receptor peptide antagonist
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PMX 205

PMX 205 is a potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's disease. Also improves hindlimb grip strength and slows disease progression in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Orally active and brain penetrant.

Technical Data for PMX 205

M. Wt 839.05
Formula C45H62N10O6
Sequence XPXWR

(Modifications: X-1 = N2-(1-Oxo-3-phenylpropyl)-Orn, X-3 = D-Cha, Lactam bridge: Orn-1 to Arg-5)
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 514814-49-4
PubChem ID 90489023
InChI Key YUIBSMOWXFHTBD-UHFFFAOYSA-N
Smiles NC(=N)NCCCC1NC(=O)C(CC2C=NC3=CC=CC=C23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C(=O)C(CCCNC1=O)NC(=O)CCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PMX 205

Solubility Soluble to 1 mg/ml in water with sonication

Product Datasheets for PMX 205

Certificate of Analysis / Product Datasheet
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Keywords: PMX 205, PMX 205 supplier, PMX205, potent, c5a, receptor, peptide, antagonist, alzheimer's, disease, alzheimers, antialzheimers, antiinflammatory, Complement, 5196, Tocris Bioscience

1 Citation for PMX 205

Citations are publications that use Tocris products. Selected citations for PMX 205 include:

Natarajan et al (2018) Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation 137 2152 PMID: 29348261

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Literature in this Area

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