PMX 205
![Cat.No. 5196 - PMX 205 | Cyclo[N2-(1-Oxo-3-phenylpropyl)-Orn-Pro-D-Cha-Trp-Arg] | CAS No. 514814-49-4](http://resources.tocris.com/images/datasheets/structures/pmx-205_5196.png "Cat.No. 5196 - PMX 205 | Cyclo[N2-(1-Oxo-3-phenylpropyl)-Orn-Pro-D-Cha-Trp-Arg] | CAS No. 514814-49-4")
Biological Activity
Potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Orally active and brain penetrant.
Technical Data
| M. Wt | 839.05 |
| Formula | C45H62N10O6 |
| Sequence |
XPXWR (Modifications: X-1 = N2-(1-Oxo-3-phenylpropyl)-Orn, X-3 = D-Cha, Lactam bridge: Orn-1 to Arg-5) |
| Storage | Store at -20°C |
| CAS Number | 514814-49-4 |
| PubChem ID | 90489023 |
| InChI Key | YUIBSMOWXFHTBD-UHFFFAOYSA-N |
| Smiles | NC(=N)NCCCC1NC(=O)C(CC2C=NC3=CC=CC=C23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C(=O)C(CCCNC1=O)NC(=O)CCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water with sonication |
Preparing Stock Solutions
The following data is based on the product molecular weight 839.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.19 mL | 5.96 mL | 11.92 mL |
| 5 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 10 mM | 0.12 mL | 0.6 mL | 1.19 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
March et al (2004) Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol.Pharmacol. 65 868 PMID: 15044616
Fonseca et al (2009) Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J.Immunol. 183 1375 PMID: 19561098
Jain et al (2013) The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Br.J.Pharmacol. 168 488 PMID: 22924972
If you know of a relevant reference for PMX 205, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PMX205 potent c5a receptor peptide antagonist alzheimer's disease alzheimers antialzheimers antiinflammatory Complement
Citations for PMX 205
Citations are publications that use Tocris products.
Currently there are no citations for PMX 205. Do you know of a great paper that uses PMX 205 from Tocris? If so please let us know.
Literature in this Area
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Immunology Product Listing
A collection of over 190 products for immunology research, the guide includes research tools for the study of:
- Chemokine and Cytokine Signaling
- Chemotaxis
- Complement System
- Immune Cell Signaling
- Inflammation
