Home / Cell Biology / Signal Transduction / Complement / Complement Antagonists / PMX 205

PMX 205

Cat. No. 5196 Datasheet / COA / SDS
Pricing Availability Delivery Time Qty
Cat.No. 5196 - PMX 205 | Cyclo[N2-(1-Oxo-3-phenylpropyl)-Orn-Pro-D-Cha-Trp-Arg] | CAS No. 514814-49-4
Description: Potent C5a receptor peptide antagonist
Datasheet
Citations
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Orally active and brain penetrant.

Technical Data

M. Wt 839.05
Formula C45H62N10O6
Sequence XPXWR

(Modifications: X-1 = N2-(1-Oxo-3-phenylpropyl)-Orn, X-3 = D-Cha, Lactam bridge: Orn-1 to Arg-5)

Storage Store at -20°C
CAS Number 514814-49-4
PubChem ID 90489023
InChI Key YUIBSMOWXFHTBD-UHFFFAOYSA-N
Smiles NC(=N)NCCCC1NC(=O)C(CC2C=NC3=CC=CC=C23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C(=O)C(CCCNC1=O)NC(=O)CCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 839.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.19 mL 5.96 mL 11.92 mL
5 mM 0.24 mL 1.19 mL 2.38 mL
10 mM 0.12 mL 0.6 mL 1.19 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

March et al (2004) Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol.Pharmacol. 65 868 PMID: 15044616

Fonseca et al (2009) Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J.Immunol. 183 1375 PMID: 19561098

Jain et al (2013) The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Br.J.Pharmacol. 168 488 PMID: 22924972

If you know of a relevant reference for PMX 205, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Complement Antagonists

Keywords: PMX 205, supplier, PMX205, potent, c5a, receptor, peptide, antagonist, alzheimer's, disease, alzheimers, antialzheimers, antiinflammatory, Complement, Complement, Tocris Bioscience

Citations for PMX 205

Citations are publications that use Tocris products.

Currently there are no citations for PMX 205. Do you know of a great paper that uses PMX 205 from Tocris? If so please let us know.

Reviews for PMX 205

There are currently no reviews for this product. Be the first to review PMX 205 and earn rewards!

Have you used PMX 205?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation