Cell Cycle Inhibitors
Cell cycle inhibitors slow or stop cell cycle progression through various mechanisms. Cell cycle arrest can be induced at different stages, decreasing the rate of cell division and the number of actively cycling cells.
Cell Cycle Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 5981 | Itraconazole |
| Inhibits cell cycle at G1 phase; also SMO antagonist | |
| 7157 | YKL 5-124 |
| Potent and selective CDK7 inhibitor; induces cell cycle arrest at the G1/S transition | |
Other |
|
| Cat. No. | Product Name / Activity |
| 4406 | 10058-F4 |
| Arrests cell cycle at G0/G1 | |
| 7680 | ABT 263 |
| Induces G1/G0 phase arrest; Bcl-2 family inhibitor | |
| 3968 | AZD 5438 |
| Blocks cell cycling at G2-M, S and G1 phases | |
| 5331 | CPI 203 |
| Arrests cell cycle at G1 phase; also BET bromodomain inhibitor | |
| 7337 | Cysmethynil |
| ICMT inhibitor; arrests cell-cycle at G1 phase | |
| 7507 | Evofosfamide |
| Hypoxia-activated DNA alkylating agent prodrug | |
| 6782 | Indisulam |
| Arrests cell cycle at G1 phase; molecular glue | |
| 1230 | Methotrexate |
| Cytotoxic agent | |
| 8122 | MR 24 |
| Induces G1 phase arrest; inhibits MST3 | |
| 3715 | Narciclasine |
| Antiproliferative agent; slows cell cycle progression | |
| 6070 | Pladienolide B |
| Arrests cell cycle in G1 and G2/M; mRNA splicing inhibitor | |
| 4763 | Pyridostatin pentahydrochloride |
| Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest | |
| 5264 | Temsirolimus |
| mTOR inhibitor; arrests cell cycle at G1/S | |
| 4282 | WYE 687 dihydrochloride |
| Potent and selective mTOR inhibitor; induces G1 cell cycle arrest | |
| 5493 | XL 413 hydrochloride |
| Potent and selective Cdc7 inhibitor | |
| 4307 | YC 1 |
| Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest | |
Literature for Cell Cycle Inhibitors
Tocris offers the following scientific literature for Cell Cycle Inhibitors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Our Cell Cycle and DNA Damage Research Guide highlights over 750 products for cell cycle and DNA damage research.
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Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Request copyDownload PDF