Cell Cycle Inhibitors

Cell cycle inhibitors slow or stop cell cycle progression through various mechanisms. Cell cycle arrest can be induced at different stages, decreasing the rate of cell division and the number of actively cycling cells.

Literature (2)

Cell Cycle Inhibitors

Cat. No. Product Name / Activity
5981 Itraconazole
Inhibits cell cycle at G1 phase; also SMO antagonist
7157 YKL 5-124
Potent and selective CDK7 inhibitor; induces cell cycle arrest at the G1/S transition


Cat. No. Product Name / Activity
4406 10058-F4
Arrests cell cycle at G0/G1
7680 ABT 263
Induces G1/G0 phase arrest; Bcl-2 family inhibitor
6827 Artesunate
Arrests cell cycle in G2/M; antimalarial
3968 AZD 5438
Blocks cell cycling at G2-M, S and G1 phases
4436 8-Chloroadenosine
Cytotoxic nucleoside analog; induces G2/M arrest
5331 CPI 203
Arrests cell cycle at G1 phase; also BET bromodomain inhibitor
7337 Cysmethynil
ICMT inhibitor; arrests cell-cycle at G1 phase
7507 Evofosfamide
Hypoxia-activated DNA alkylating agent prodrug
1813 Indirubin-3'-oxime
Induces cell cycle arrest, antiproliferative
6782 Indisulam
Arrests cell cycle at G1 phase; molecular glue
1230 Methotrexate
Cytotoxic agent
5231 MPC 6827 hydrochloride
Inhibitor of microtubule polymerization; antimitotic and antitumor
3715 Narciclasine
Antiproliferative agent; slows cell cycle progression
6070 Pladienolide B
Arrests cell cycle in G1 and G2/M; mRNA splicing inhibitor
4763 Pyridostatin pentahydrochloride
Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
5264 Temsirolimus
mTOR inhibitor; arrests cell cycle at G1/S
4282 WYE 687 dihydrochloride
Potent and selective mTOR inhibitor; induces G1 cell cycle arrest
5493 XL 413 hydrochloride
Potent and selective Cdc7 inhibitor
4307 YC 1
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Literature for Cell Cycle Inhibitors

Tocris offers the following scientific literature for Cell Cycle Inhibitors to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.